PMID: 11925453Apr 2, 2002Paper

Quercetin-3-glucoside is transported by the glucose carrier SGLT1 across the brush border membrane of rat small intestine

The Journal of Nutrition
S WolfframP Ader

Abstract

In the present study we investigated a possible involvement of the intestinal sodium-dependent glucose transporter (SGLT)1 in the absorption of quercetin-3-glucoside (Q3G). Pieces of rat jejunum or proximal colon were mounted in Ussing-type chambers and incubated under short-circuited conditions. Test flavonols were added to the mucosal or serosal bathing solution (initial concentration, 100 micromol/L) and disappearance from the donor compartment was monitored for 2 h. With jejunal tissue, only 13.6 +/- 3.5% of the initial dose of Q3G was found in the mucosal compartment 2 h after mucosal addition. Simultaneous addition of D-glucose (10 mmol/L) significantly reduced the disappearance of Q3G (remaining concentration, 33.4 +/- 6.9%) as did a Na(+)-free buffer solution containing phloridzin (final mucosal concentration of Q3G, 54.2 +/- 7.7%). In these experiments, disappearance of Q3G was paralleled by the appearance of quercetin in the mucosal solutions. In contrast, D-fructose (10 mmol/L) did not influence the disappearance of Q3G (Na(+)-free conditions). With proximal colon, 78.2 +/- 11.5% of the initial concentration of Q3G was still present in the mucosal solution after 2 h. When added to the serosal side, the concentration ...Continue Reading

References

Dec 1, 1995·The American Journal of Clinical Nutrition·P C HollmanM B Katan
Jul 1, 1995·The Journal of Nutrition·C ManachC Rémésy
Dec 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J V Formica, W Regelson
Jan 13, 1997·FEBS Letters·G Paganga, C A Rice-Evans
May 1, 1997·The American Journal of Clinical Nutrition·M G HertogD Kromhout
Jul 1, 1997·The Journal of Nutrition·J SfakianosS Barnes
Feb 19, 1998·Zeitschrift für Ernährungswissenschaft·J LinseisenG Wolfram
Jul 9, 1998·Free Radical Biology & Medicine·J M GeeI T Johnson
Aug 28, 1998·Bioscience, Biotechnology, and Biochemistry·K IokuJ Terao
Jun 1, 2000·Free Radical Biology & Medicine·P AderS Wolffram
Dec 29, 2000·Phytochemistry·J B Harborne, C A Williams
Mar 17, 2001·The Journal of Physiology·G L Kellett
May 22, 2001·Journal of Clinical Pharmacology·E U GraefeM Veit
Jun 13, 2001·Methods in Enzymology·O DanglesC Remesy

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Citations

Mar 31, 2004·The Journal of Nutrition·Amy D MackeyJesse F Gregory
Jul 22, 2009·Bioorganicheskaia khimiia·Seyed Mehdi RazaviSariyeh Mohammadi
May 16, 2014·Nutrition Reviews·Torsten Bohn
Oct 27, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Stuart AstburyRhonda C Bell
Aug 11, 2019·Pharmaceuticals·Marija Lesjak, Surjit K S Srai
Mar 1, 2020·International Journal of Molecular Sciences·Kristina FerenczyovaMonika Bartekova
Mar 4, 2003·The Journal of Nutrition·Aloys L A SesinkPeter C H Hollman
Jun 9, 2004·The British Journal of Nutrition·Rainer CermakSiegfried Wolffram
May 14, 2004·Nutrition Journal·Jeanelle Boyer, Rui Hai Liu
Apr 14, 2006·The British Journal of Nutrition·Catherine FelginesFabio Galvano
Aug 31, 2004·The Journal of Nutrition·Séverine TalavéraChristian Rémésy
Apr 20, 2012·Journal of Medicinal Food·Julio WainsteinZecharia Madar
Sep 17, 2015·Journal of Food Science·Yasuaki KashinoJunji Terao
Dec 27, 2017·Current Medicinal Chemistry·Antoni SuredaSilvia Tejada
Oct 28, 2019·Critical Reviews in Food Science and Nutrition·Iveta NajmanováPřemysl Mladěnka
Jun 3, 2004·The Journal of Nutrition·Stephanie LesserSiegfried Wolffram
Dec 19, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Oran KwonMark Levine
Apr 7, 2009·Applied and Environmental Microbiology·Jules BeekwilderRobert D Hall
Apr 1, 2008·Nutrition Research and Practice·Mi-Young ParkMi-Kyung Sung
May 9, 2007·Journal of Nutritional Science and Vitaminology·Kazuhiro EmuraMasamitsu Moriwaki
Sep 2, 2003·The Journal of Nutrition·Rainer CermakSiegfried Wolffram
Jul 23, 2008·Molecular Nutrition & Food Research·Catherine FelginesFabio Galvano
May 25, 2013·Clinical Pharmacokinetics·Christian UdeMario Wurglics
Jun 12, 2009·Medicine and Science in Sports and Exercise·David C NiemanThomas C Lines
Nov 30, 2014·Human Molecular Genetics·Diana MacedoCláudia N Santos
May 30, 2015·Nutrition Reviews·Danielle M StringerCarla G Taylor
Oct 30, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marko VidakRadovan Komel
Dec 15, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jian ShiZhongqiu Liu
Sep 16, 2017·Journal of Food and Drug Analysis·Bing HuXiaoxiong Zeng
May 3, 2006·Archives of Animal Nutrition·Rainer Cermak, GerhardBrLüpke MatthiaseWolffram Siegrfried Breves
Apr 28, 2006·Clinical Pharmacokinetics·Mario Wurglics, Manfred Schubert-Zsilavecz
Sep 29, 2005·Molecular Nutrition & Food Research·Franck TourniaireMarie-Josèphe Amiot
Feb 2, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yoshinori MarunakaAkiyuki Taruno
Feb 14, 2015·Journal of Cellular Biochemistry·Michael A Lea
Sep 15, 2015·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Robert R MaronpotShim-Mo Hayashi
Mar 4, 2014·PloS One·Pia V RöderHannelore Daniel

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