Quercetin, a Flavonoid Antioxidant, Ameliorated Procarbazine-Induced Oxidative Damage to Murine Tissues

Antioxidants
Ebenezer Tunde OlayinkaRoseline Chinonye Echebiri

Abstract

Procarbazine (PCZ) (indicated in Hodgkin's disease), is an alkylating agent known to generate free radicals in vivo, while Quercetin (QCT) is a flavonoid antioxidant with proven free radical scavenging capacity. This study investigated the protective effects of QCT on PCZ-induced oxidative damage in the rat. Male Wistar rats (160-180 g) were randomized into five groups (n = 5/group): I (control), II PCZ-treated (2 mg/kg body weight (bw) for seven days); III pre-treated with QCT (20 mg/kg bw) for seven days, followed by PCZ for seven days; IV co-treated with PCZ and QCT for seven days and V administered QCT alone for seven days. PCZ caused a significant increase in plasma total bilirubin, urea, and creatinine when compared with control (P < 0.05). Similarly, plasma activities of alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyl transferase (γ-GT) were significantly increased in the PCZ-treated group relative to control. Furthermore, PCZ caused a significant decrease in the activities of hepatic superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST) as well as levels of ascorbic acid (AA) and glutathione (GSH). This was followed by a significant in...Continue Reading

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Citations

Jul 6, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kun-Chang WuYuan-Shiun Chang
May 22, 2019·Antioxidants·Carmen Rodríguez-GarcíaJosé J Gaforio
Aug 3, 2018·Porto Biomedical Journal·Ebenezer Tunde OlayinkaOlaniyi Solomon Ola
Mar 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dong XuYuan-Lu Cui
Dec 8, 2020·BioMed Research International·Pedro A Machado-JuniorSílvia D Cangussú

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