PMID: 70222Aug 15, 1977Paper

Quercetin: a novel inhibitor of Ca2+ influx and exocytosis in rat peritoneal mast cells

Biochimica Et Biophysica Acta
C M Fewtrell, B D Gomperts

Abstract

The effect of the transport ATPase inhibitor, quercetin on histamine secretion from antigen sensitized mast cells was examined. At micromolar concentrations, quercetin had an immediate inhibitory effect on histamine secretion mediated by antigen, concanavalin A and ATP but it had little effect on release induced by the ionophores A23187 and X537A. Quercetin exerts its effect after the binding of the releasing ligands and the distinction between its effect on ligand induced and A23187 induced secretion suggests that it affects the normal path of Ca2+ entry into the cell. The inhibitory effects of quercetin were compared with those of the structurally related anti-allergic drugs cromoglycate and AH7725.

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Citations

Apr 20, 1978·The Journal of Membrane Biology·D W SalterJ S Cook
Apr 25, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Miyoko MatsushimaTsutomu Kawabe
Mar 27, 1992·Biochemical Pharmacology·E Middleton, C Kandaswami
Apr 1, 1982·Immunopharmacology·A SchwartzE Middleton
Jan 1, 1979·International Journal of Immunopharmacology·C W BiermanJ L Mongar
Jan 1, 1985·General Pharmacology·K OhishiM K Uchida
Apr 29, 1998·International Journal for Parasitology·I Scott, Q A McKellar
Nov 28, 2002·Pharmacology & Therapeutics·Bent H Havsteen
Jul 16, 1999·International Journal of Immunopharmacology·M AlexandrakisT C Theoharides
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·N MazurekI Pecht
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·N MazurekI Pecht
Dec 1, 1987·The Journal of Cell Biology·Z Y LiuE L Elson
Jan 1, 1981·Journal of Biomechanics·N Akkas
Jun 1, 1984·The Journal of Allergy and Clinical Immunology·J C Foreman
Dec 16, 1983·Biochemical and Biophysical Research Communications·M GschwendtF Marks
Nov 1, 1984·Biochemical Pharmacology·E Middleton, G Drzewiecki
Jan 1, 1983·Biochemical Pharmacology·P V Kaplita, D J Triggle
Jul 28, 2004·Journal of Herbal Pharmacotherapy·Eman G HaggagTheoharis C Theoharides
Feb 13, 2013·International Immunopharmacology·Marcela de Souza SantosRose Mary Zumstein Georgetto Naal
May 18, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jiri MlcekJiri Sochor
Sep 14, 1981·Biochimica Et Biophysica Acta·J A Runquist, P A Loach
Oct 1, 1981·Biochemical Pharmacology·E MiddletonD Triggle

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