Quercetin administration during chelation therapy protects arsenic-induced oxidative stress in mice

Biological Trace Element Research
Deepshikha Mishra, Swaran J S Flora

Abstract

We studied the efficacy of quercetin and a thiol chelating agent, monoisoamyl 2, 3-dimercaptosuccinic acid (MiADMSA) either individually or in combination against arsenic-induced oxidative stress and mobilization of metal in mouse. Animals were chronically exposed to 25 ppm arsenite as sodium arsenite in drinking water for 12 months followed by treatment with MiADMSA (0.2 mmol/kg, orally), quercetin (0.2 mmol, orally) either alone or in combination, once daily for 5 consecutive days. Arsenic exposure led to a significant depletion of blood delta-aminolevulinic acid dehydratase (ALAD) activity, glutathione, white (WBC) and red blood cell (RBC) counts, and an increase in platelet levels while significantly increasing the level of reactive oxygen species (in RBCs). Hepatic reduced catalase (CAT) and glutathione peroxidase activities showed a depletion, whereas thiobarbituric acid reactive substances (TBARS) levels increased on arsenic exposure indicating arsenite-induced oxidative stress in blood and liver. Kidney CAT activity showed a depletion, whereas TBARS levels increased on arsenic exposure. These biochemical changes were accompanied by an increase in blood, liver, and kidney arsenic concentration. Treatment with MiADMSA was...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Feb 1, 1991·Journal of Applied Toxicology : JAT·G S Ding, Y Y Liang
Jun 1, 1972·Analytical Biochemistry·A K Sinha
Jan 1, 1983·Annual Review of Pharmacology and Toxicology·H V Aposhian
Apr 1, 1984·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·H V AposhianE Stine
Jan 1, 1984·Methods in Enzymology·L Flohé, W A Günzler
Feb 1, 1995·Environmental Health Perspectives·O RamosF Díaz-Barriga
Apr 1, 1995·Free Radical Research·C A Rice-EvansJ B Pridham
Aug 25, 1995·Biochemical Pharmacology·I B Afanas'evL G Korkina
Apr 1, 1995·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·S J FloraP R Malhotra
Aug 1, 1994·Journal of Toxicology and Environmental Health·M A BosqueP K Singh
Jan 4, 1998·Journal of Gastroenterology and Hepatology·C J ChenY F Liaw
Oct 29, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P C Hollman, M B Katan
Aug 5, 2000·The Journal of Nutrition·A Scalbert, G Williamson
Mar 26, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Iván Csanaky, Zoltán Gregus
May 14, 2003·Digestive Diseases and Sciences·Amalia PavanatoNorma Marroni
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Mar 10, 2004·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Young-Hyun Park, George C Y Chiou
Apr 17, 2004·Ecotoxicology and Environmental Safety·Gurusamy M Kannan, Swaran J S Flora
Oct 7, 2004·European Journal of Pharmacology·Jean-Claude StocletValérie B Schini-Kerth
Dec 18, 2004·Toxicologic Pathology·Ricardo N Pires das NevesMaria Lourdes de Pereira
Feb 11, 2005·Journal of Occupational Health·Kiran Kalia, Swaran J S Flora
Mar 22, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Eun Jeong ChoiKew-Mahn Chee
Jan 25, 2006·Chemico-biological Interactions·M ValkoM Mazur
Apr 18, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·B H HansenR A Andersen
Jun 16, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D NandiD Swarup

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Citations

Aug 5, 2009·Biological Trace Element Research·Patricia A M WilliamsEnrique J Baran
Apr 20, 2011·Clinical and Experimental Pharmacology & Physiology·Swaran J S FloraPramod K Kushwah
Aug 19, 2010·International Journal of Environmental Research and Public Health·Swaran J S Flora, Vidhu Pachauri
Aug 6, 2015·Biological Trace Element Research·Munesh KumarRajesh Thakur
Sep 11, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·K M Denny Joseph, Muralidhara
Jul 27, 2011·Environmental Toxicology and Pharmacology·Chan-Min LiuYun-Zhi Sun
Aug 20, 2010·Ecotoxicology and Environmental Safety·Anshu JainS J S Flora
Jul 1, 2009·Environmental Toxicology and Pharmacology·Kapil Bhatt, S J S Flora
Jan 15, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Roberta de P MartinsMarcelo Farina
Apr 1, 2016·Expert Opinion on Drug Delivery·Abhishek Yadav, Swaran Jeet Singh Flora
Sep 4, 2014·BioMed Research International·Bechan SharmaNikhat J Siddiqi
May 11, 2011·Free Radical Biology & Medicine·Swaran J S Flora
Mar 13, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·S Sachdeva, S J S Flora
Dec 15, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mehmet KanterMustafa Erboga
Jun 21, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Haiyan ZhuXinxin Liu
Sep 3, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Periasamy Ramyaa, Viswanadha Vijaya Padma
Dec 1, 2015·Biochemistry Research International·Vivek Kumar GuptaBechan Sharma
Oct 2, 2012·Toxicology and Industrial Health·Neha P SangaiMrugesh H Trivedi
Nov 13, 2015·Canadian Journal of Physiology and Pharmacology·Ichraf SfaxiEzzedine Aouani
May 13, 2019·Environmental Science and Pollution Research International·Cecilia Nwadiuto AmadiOrish Ebere Orisakwe
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ann SusanUma Maheswari Krishnan
Aug 25, 2021·Environmental Pollution·Md Shiblur RahamanSahoko Ichihara

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