Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-κB pathway

International Immunopharmacology
Haiming ChenLing Han

Abstract

Quercetin (QC) is a dietary flavonoid abundant in many natural plants. A series of studies have shown that it has been shown to exhibit several biological properties, including anti-inflammatory, anti-oxidant, cardio-protective, vasodilatory, liver-protective and anti-cancer activities. However, so far the possible therapeutic effect of QC on psoriasis has not been reported. The present study was undertaken to evaluate the potential beneficial effect of QC in psoriasis using a generated imiquimod (IMQ)-induced psoriasis-like mouse model, and to further elucidate its underlying mechanisms of action. Effects of QC on PASI scores, back temperature, histopathological changes, oxidative/anti-oxidative indexes, pro-inflammatory cytokines and NF-κB pathway in IMQ-induced mice were investigated. Our results showed that QC could significantly reduce the PASI scores, decrease the temperature of the psoriasis-like lesions, and ameliorate the deteriorating histopathology in IMQ-induced mice. Moreover, QC effectively attenuated levels of TNF-α, IL-6 and IL-17 in serum, increased activities of GSH, CAT and SOD, and decreased the accumulation of MDA in skin tissue induced by IMQ in mice. The mechanism may be associated with the down-regulatio...Continue Reading

Citations

Jun 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bing-You YangHai-Xue Kuang
Nov 2, 2019·Bioscience Reports·Xiran LinZhiqi Song
Mar 18, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Bruna da Silveira de MattosRoselia Maria Spanevello
Apr 20, 2018·Scientific Reports·Yi YangShao-Jun Tang
May 10, 2018·Frontiers in Pharmacology·Spencer DunawayAna L Kadekaro
Mar 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dong XuYuan-Lu Cui
Aug 23, 2019·Therapeutic Advances in Chronic Disease·Hristina KocicKetty Peris
Jul 14, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Lin ZhouDisheng Tao
Oct 22, 2020·Critical Reviews in Food Science and Nutrition·Ankita KumariRajeev Kapila
Nov 5, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Jing FuPing Li
Apr 17, 2021·International Immunopharmacology·Chung-Chi YangChi-Feng Hung
Apr 12, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J FrankovaJ Ulrichova
Aug 7, 2021·Redox Report : Communications in Free Radical Research·Dehai XianJianqiao Zhong

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