Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-κB signaling in A549 cells

Chemico-biological Interactions
Tzu-Chin WuShu-Lan Yeh

Abstract

Nickel exposure promotes the invasive potential of human lung cancer cells. Polyphenols such as quercetin, curcumin, chrysin, apigenin, and luteolin, present in many plant foods may suppress the development of cancers. However, whether these compounds inhibit the promoting effects of Nickel on cancer cell invasion and migration as well as the possible mechanisms are unclear. In the present study, we first showed that quercetin, curcumin, chrysin, apigenin, and luteolin at 5 μM, significantly suppressed the promoting effects of NiCl2 (Ni) on migration and invasion in H1975 and A549 human lung cancer cells. The five phytochemicals also significantly suppressed the secretion of cytokines, IL-1β, IL-6, TNF-α and IL-10, induced by Ni in A549 cells. The overall efficiency of quercetin was the best, followed by chrysin and the other compounds. Furthermore, we found that quercetin and chrysin suppressed the mRNA and protein expression of TLR4 and Myd88. Consistently, quercetin and chrysin also decreased the phosphorylation of IKKβ and IκB, the nuclear level of p65 (NF-κB) as well as the expression of MMP-9 in A549 cells exposed to Ni. In conclusion, these results suggest the potential preventive effects of the five phytochemicals on th...Continue Reading

References

May 6, 2004·Bioorganic & Medicinal Chemistry Letters·Andrew BaxterYafeng Xue
Sep 17, 2004·Genes & Development·Matthew S Hayden, Sankar Ghosh
Apr 29, 2006·Molecular and Cellular Biochemistry·M R VijayababuJ Arunakaran
Jun 9, 2006·Journal of Toxicology and Environmental Health. Part a·Chung-Yih KuoHuei Lee
Mar 30, 2007·The Journal of Biological Chemistry·Andrei E MedvedevStefanie N Vogel
May 12, 2009·Biochemical Pharmacology·Jun Kyung LeeJoo Young Lee
Jun 11, 2009·Molecular Cancer Therapeutics·Qiong ZhouJing Fang
Jan 21, 2010·British Journal of Cancer·Y Wu, B P Zhou
Aug 19, 2010·Oxidative Medicine and Cellular Longevity·Kanti Bhooshan Pandey, Syed Ibrahim Rizvi
Sep 22, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yihua SunHongbin Ji
Sep 4, 2012·Archives of Pharmacal Research·Shaherin BasithSangdun Choi
Jun 8, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wen-Wei SungHuei Lee
Aug 1, 2014·Frontiers in Immunology·Dhanusha YesudhasSangdun Choi
May 23, 2015·Cancer Research·Sophia Ran
Dec 8, 2015·Environment International·O Raaschou-NielsenP Vineis

❮ Previous
Next ❯

Citations

Jan 17, 2019·Cardiovascular & Hematological Agents in Medicinal Chemistry·Tahereh FarkhondehFereshteh Bafandeh
Jan 23, 2020·International Journal of Molecular Sciences·Yu-Ting KangJiunn-Liang Ko
May 9, 2019·Journal of Cellular Physiology·Chih-Hsien WuYu-Ping Hsiao
Oct 1, 2020·Biomolecules·Ebrahim Rahmani MoghadamAlan Prem Kumar
Oct 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mai KhaterHelen M I Osborn
Feb 13, 2021·Molecular Genetics and Genomics : MGG·Zhendong LiuXingyong Shen
Nov 27, 2020·Osteoarthritis and Cartilage·Zhenxuan ShaoXiaolei Zhang
Feb 26, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Ho-Sung LeeDae-Yeon Lee
Mar 2, 2021·Food Research International·Bibiana SilvaAna Carolina Oliveira Costa
Apr 1, 2021·Phytotherapy Research : PTR·Abhishek GourUtpal Nandi
Apr 17, 2021·Cancer Cell International·Marjan TalebiSaeed Samarghandian
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luis Gustavo Saboia PonteFernando Moreira Simabuco
Jul 21, 2020·Ecotoxicology and Environmental Safety·Hongrui GuoHuaqiao Tang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.