Quercetin as an anticancer agent: Focus on esophageal cancer.

Journal of Food Biochemistry
Amirhossein DavoodvandiSadegh Jafarnejad

Abstract

Esophageal cancer (EC) is regarded as the sixth highest contributor to all cancer-related mortality, worldwide. In spite of advances in the treatment of EC, currently used methods remain ineffective. Quercetin, as a dietary antioxidant, is a plant flavonol from the flavonoid group of polyphenols, and can be found in numerous vegetables, fruits, and herbs. Quercetin can affect the processes of cancer-related diseases via cell proliferation inhibitory effects, potential apoptosis effects, and antioxidant properties. Of the various types of cancer, the use of quercetin has now become prominent in the treatment of EC. In this review, we discuss how quercetin may be an important supplement for the prevention, treatment, and management of EC, owing to its natural origin, and low-cost relative to synthetic cancer drugs. However, most findings cited in the current study are based on in vitro and in vivo studies, and thus, further human-based research is necessitated. PRACTICAL APPLICATIONS: In spite of advances in the treatment of esophageal cancer, currently used methods remain ineffective, therefore, an alternative or complementary therapy is required. Quercetin, as a dietary antioxidant, can affect the processes of cancer-related di...Continue Reading

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Citations

Dec 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lourdes Alvarez-ArellanoJuan Carlos Corona
Oct 17, 2020·Biochemical and Biophysical Research Communications·Jiajia ZhangJunping Wang
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Saleh A AlmatroodiArshad Husain Rahmani
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hui-Fang ChiuChin-Kun Wang
Sep 18, 2021·Natural Product Research·Carla Di ChioRoberta Ettari

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