Quercetin attenuates adipose hypertrophy, in part through activation of adipogenesis in rats fed a high-fat diet.

The Journal of Nutritional Biochemistry
Diahann J PerdicaroMarcela A Vazquez Prieto

Abstract

An impaired capacity of adipose tissue expansion leads to adipocyte hypertrophy, inflammation and insulin resistance (IR) under positive energy balance. We previously showed that a grape pomace extract, rich in flavonoids including quercetin (Q), attenuates adipose hypertrophy. This study investigated whether dietary Q supplementation promotes adipogenesis in the epididymal white adipose tissue (eWAT) of rats consuming a high-fat diet, characterizing key adipogenic regulators in 3T3-L1 pre-adipocytes. Consumption of a high-fat diet for 6 weeks caused IR, increased plasma TNFα concentrations, eWAT weight, adipocyte size and the eWAT/brown adipose tissue (BAT) ratio. These changes were accompanied by decreased levels of proteins involved in angiogenesis, VEGF-A and its receptor 2 (VEGF-R2), and of two central adipogenic regulators, i.e. PPARγ and C/EBPα, and proteins involved in mature adipocyte formation, i.e. fatty acid synthase (FAS) and adiponectin. Q significantly reduced adipocyte size and enhanced angiogenesis and adipogenesis without changes in eWAT weight and attenuated systemic IR and inflammation. In addition, high-fat diet consumption increased eWAT hypoxia inducible factor-1 alpha (HIF-1α) levels and those of protein...Continue Reading

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Citations

Aug 23, 2020·Biomedicines·Shoib Sarwar SiddiquiCijo George Vazhappilly
Dec 16, 2020·The Journal of Nutritional Biochemistry·Richard S BrunoNaima Moustaid-Moussa
Feb 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ki-Shuk ShimHyunil Ha
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giuseppe MontalbanoAntonino Germanà
Aug 7, 2021·Ultrasonics Sonochemistry·Muhammad Faisal ManzoorBin Xu
Sep 29, 2021·Journal of Agricultural and Food Chemistry·Yu WangXingbin Yang

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