Quercetin attenuates hypertension induced by sodium fluoride via reduction in oxidative stress and modulation of HSP 70/ERK/PPARγ signaling pathways

BioFactors
Ademola Adetokunbo OyagbemiMomoh Audu Yakubu

Abstract

Hypertension is one of the silent killers in the world with high mortality and morbidity. The exposure of humans and animals to fluoride and/or fluoride containing compounds is almost inevitable. This study investigated the modulatory effects of quercetin on sodium fluoride (NaF)-induced hypertension and cardiovascular complications. Forty male rats were randomly separated into four groups (n =10). Group A animals served as the control, rats in Group B were exposed to 300 ppm of NaF, Groups C and D animals were exposed to 300 ppm of NaF along with quercetin orally at 50 mg/kg and 100 mg/kg orally by gavage, while NaF was administered in drinking water, respectively, for a week. Administration of NaF caused severe hypertension as indicated with significant increases in the systolic, diastolic, and mean arterial blood pressure, together with prolonged ventricular depolarization (QRS) and the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle (QT) intervals when compared with controls. NaF significantly decreased the activities of antioxidant enzymes, caused increase in markers of oxidative stress and renal damage when compared with controls. Immunohistochemical staining revealed lower e...Continue Reading

References

Nov 1, 1990·International Journal of Radiation Biology·R Varshney, R K Kale
Jun 1, 1972·Analytical Biochemistry·A K Sinha
Feb 1, 1997·Analytical Biochemistry·Y Xia, J L Zweier
Nov 8, 2001·European Journal of Pharmacology·W MacNee
Apr 23, 2003·Hypertension·Josep RedónGuillermo T Sáez
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Dec 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Giuseppe PetrosilloGiuseppe Paradies
Oct 30, 2004·Acta Odontologica Scandinavica·Svante TwetmanBirgitta Söder
Jan 29, 2005·Journal of Agricultural and Food Chemistry·Ho Jin Heo, Chang Yong Lee
Jul 26, 2006·Hypertension·Maria Carolina GongoraDavid G Harrison
Aug 18, 2006·The Veterinary Journal·Jens Lykkesfeldt, Ove Svendsen
Jun 26, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Tetsuji ShinoharaHironobu Yoshimatsu
Sep 19, 2007·World Journal of Gastroenterology : WJG·Samuel Babafemi OlaleyeOlasupo Sunday Adeniyi
Jan 24, 2008·Biochemical and Biophysical Research Communications·Jianfei JiangValerian E Kagan
Apr 18, 2008·European Journal of Pharmacology·Agnes W BootsAalt Bast
Jun 20, 2008·The International Journal of Biochemistry & Cell Biology·Joe W Ramos
Mar 18, 2009·Immunological Reviews·Mercedes Rincón, Roger J Davis
Jun 6, 2009·Journal of Dental Research·H KarubeM Matsuoka
Mar 11, 2010·Biological Trace Element Research·Wenjing ZhuZigui Zhang
Jun 22, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Flori R SariKenichi Watanabe
Jul 7, 2011·Hypertension·Heinrich E LobDavid G Harrison
Aug 23, 2011·Biochemical Pharmacology·Maria RussoGian Luigi Russo
Feb 9, 2012·Food & Function·Seyed Fazel NabaviAkbar Hajizadeh Moghaddam
Sep 18, 2012·Antioxidants & Redox Signaling·Chu-Chiao Wu, Shawn B Bratton
Jun 6, 2013·Oxidative Medicine and Cellular Longevity·Paula Mochidome YamagutiJosé Nicolau
Jul 23, 2013·Frontiers in Genetics·Lidiya LuzhnaOlga Kovalchuk
Dec 24, 2013·Journal of Biomedical Science·Jing-Yi ChenHsiu-Chuan Chou
Apr 8, 2014·Environmental Toxicology·Ademola Adetokunbo OyagbemiOluwabusola Daramola
Apr 17, 2015·Pharmaceutical Biology·Sarawut KumphuneNipon Chattipakorn
Sep 15, 2016·Acta Odontologica Scandinavica·Lin ZhaoJianping Ruan
Dec 28, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Josef RoslanNaguib Salleh
Mar 24, 2017·EBioMedicine·Zhen-Guo MaQi-Zhu Tang

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Citations

Jul 25, 2019·Journal of Biochemical and Molecular Toxicology·Yueming ZhangXiaoyu Qu
Sep 23, 2020·Phytotherapy Research : PTR·Mojtaba YousefiAmir M Mortazavian
Sep 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lorena CiumărneanGabriela Dogaru
Oct 27, 2020·Frontiers in Veterinary Science·Mengwei LiChengjian Yang
Mar 18, 2021·European Journal of Pharmacology·Simona SaponaraMassimo Valoti

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