Quercetin attenuates Staphylococcus aureus virulence by reducing alpha-toxin secretion

Revista Argentina de microbiología
Gabriela Carrada López, Carlos A Castañón Sánchez

Abstract

Alpha toxin, a pore-forming protein with cytotoxic activity, is one of the major virulence factors secreted by most strains of Staphylococcus aureus. The relevance of this protein in the pathogenesis of pneumonia associated with S.aureus infections has already been established. Therefore, inhibiting alpha toxin secretion can be an alternative for controlling these infections. This study shows that quercetin, a naturally occurring flavonoid, inhibits hemolytic activity in a dose-dependent manner and reduces alpha toxin secretion in culture supernatants of methicillin-sensitive and methicillin-resistant S.aureus. Furthermore, quercetin significantly prevents damage to human alveolar cells when co-cultured with S.aureus. Our results suggest that quercetin can reduce S.aureus virulence by affecting alpha-toxin secretion.

Citations

Nov 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Francesca GuzzoBrigida D'Abrosca
Nov 9, 2019·Journal of Agricultural and Food Chemistry·Shuai-Cheng WuJian-Zhong Shen

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