Quercetin conjugated poly(β-amino esters) nanogels for the treatment of cellular oxidative stress

Acta Biomaterialia
Prachi GuptaThomas D Dziubla

Abstract

PβAE polymers have emerged as highly promising candidates for biomedical and drug delivery applications owing to their tunable, degradable and pH sensitive properties. These polymeric systems can serve as prodrug carriers for the delivery of bioactive compounds which suffer from poor aqueous solubility, low bioavailability and are biologically unstable, such as the antioxidant, quercetin. Using acrylate functionalized quercetin, it is possible to incorporate the polyphenol into the backbone of the polymer matrix, permitting slow release of the intact molecule which is perfectly timed with the polymer degradation. While formulating these quercetin conjugated PβAE matrix into nanocarriers would allow for multiple delivery routes (oral, intravenous, inhalation etc.), well known oil-water nano-emulsion formulation methods are not amenable to the crosslinked hydrolytically sensitive nanoparticle/nanogel. In this work, a single-phase reaction-precipitation method was developed to formulate quercetin conjugated PβAE nanogels (QNG) via reaction of acrylated quercetin (4-5 acrylate groups) with a secondary diamine under dilute conditions using acetonitrile as the reaction medium, resulting in a self-stabilized suspension. The proposed a...Continue Reading

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Citations

Aug 6, 2016·International Journal of Pharmaceutics·Prachi GuptaThomas D Dziubla
Aug 9, 2016·Natural Product Research·Xiomara Patricia Perea-DomínguezSergio Medina-Godoy
Jul 1, 2017·Journal of Natural Products·Vinod S PatilThomas D Dziubla
Dec 15, 2018·Advanced Healthcare Materials·Yong LiuLinqi Shi
Nov 2, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Pei WangTingfei Xi
Jan 1, 2020·Cancers·Sue Anne ChewSerena Danti
Jan 1, 2020·Antioxidants·Ibrahim KhalilAli Seyfoddin
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Jul 27, 2021·Journal of Agricultural and Food Chemistry·David Julian McClements, Bengü Öztürk
Aug 22, 2017·ACS Applied Materials & Interfaces·M Arif KhanBarbara L Knutson

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