Abstract
Treated glioblastoma multiforme (GBM) patients only survive 6 to 14months after diagnosis; therefore, the development of novel therapeutic strategies to treat gliomas remains critically necessary. Considering that phenolic compounds, like quercetin, have the potential to be used in the chemotreatment of gliomas and that some flavonoids exhibit the ability to cross the BBB, in the present study, we investigated the antitumor effect of flavonoids (including chalcones, flavones, flavanones and flavonols). Initially their activities were tested in C6 glioma cells screened using the MTT method, resulting in the selection of chalcone 2 whose feasibility was confirmed by a Trypan Blue exclusion assay in the low μM range on C6 glioma cells. Cell cycle and apoptotic death analyses on C6 glioma cells were also performed, and chalcone 2 increased the apoptosis of the cells but did not alter the cell cycle progression. In addition, treatments with these two compounds were not cytotoxic to hippocampal organotypic cultures, a model of healthy neural cells. Furthermore, the results indicated that 2 induced apoptosis by inhibition of NF-κB and activation of active caspase-3 in glioma cells, suggesting that it is a potential prototype to develo...Continue Reading
References
Dec 1, 1979·Analytical Biochemistry·G L Peterson
Apr 1, 1991·Journal of Neuroscience Methods·L StoppiniD Muller
Sep 6, 2002·Biochemical Pharmacology·Alok C Bharti, Bharat B Aggarwal
Apr 18, 2003·Neuroscience·L M ValentimC G Salbego
Feb 26, 2004·Free Radical Biology & Medicine·Kuresh A YoudimN Joan Abbott
Apr 28, 2005·Virchows Archiv : an International Journal of Pathology·Xavier DolcetXavier Matias-Guiu
Oct 4, 2005·The Journal of Clinical Investigation·Jun-Li LuoMichael Karin
Aug 19, 2006·Anti-cancer Drugs·Elizandra BraganholAna M O Battastini
Mar 27, 2007·Bioorganic & Medicinal Chemistry·Mauricio CabreraMercedes González
Apr 28, 2007·Cellular Signalling·Long HeJong Seog Ahn
May 24, 2007·Cancer·Sith SathornsumeteeJeremy N Rich
Jul 24, 2007·Biochimica Et Biophysica Acta·Elizandra BraganholAna M O Battastini
May 6, 2008·Investigational New Drugs·Mario Luiz Conte da FrotaJosé Cláudio Fonseca Moreira
Apr 1, 2009·International Journal of Molecular Sciences·Cesar EcheverriaRodrigo Ramirez-Tagle
Jun 6, 2009·Cancer Science·Lauren L ZaminGuido Lenz
Jul 22, 2009·BMC Cancer·Ahcene BoumendjelJean Boutonnat
Nov 4, 2009·Journal of Medicinal Chemistry·Balasubramanian SrinivasanChengguo Xing
Dec 1, 2009·Neurosurgery Clinics of North America·Jianfei JiJohn S Yu
Dec 5, 2009·Neuroimaging Clinics of North America·H Ian RobinsDeepak Khuntia
Jan 13, 2010·Bioorganic & Medicinal Chemistry·Babasaheb P BandgarChandrahas N Khobragade
Mar 10, 2010·Neurochemical Research·Jader NonesFlávia Carvalho Alcantara Gomes
May 11, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Martina PilatovaJan Mojzis
Jul 17, 2010·Planta medica·Sahdeo PrasadBharat B Aggarwal
Nov 3, 2010·Biochemical Pharmacology·Alfeu Zanotto-FilhoJosé Cláudio Fonseca Moreira
Aug 27, 2011·Biochemical and Biophysical Research Communications·Mi Hee Park, Do Sik Min
Jan 3, 2012·European Journal of Medicinal Chemistry·Tânia R MielckeMaria M Campos
May 12, 2012·Current Pharmaceutical Design·Paul A Lapchak
Jul 15, 2011·Food Chemistry·B L SantosS L Costa
Mar 19, 2013·Annual Review of Biophysics·Johanna Napetschnig, Hao Wu
Apr 27, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Yuxin ZhouQinglong Guo
May 6, 2014·Journal of Neuro-oncology·Malini MukherjeeDebananda Pati
Citations
Aug 25, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nur Izzati IsmailMohd Roslan Sulaiman
Feb 6, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Paola Dell'AlbaniMario C Foti
Feb 23, 2018·Chemical Biology & Drug Design·Yan-Cheng WuZhao-Yang Wang
Dec 28, 2019·BioFactors·Erfan TavanaAmirhossein Sahebkar
Nov 16, 2018·Molecular Medicine Reports·Jin YiJun Fei
Jun 27, 2019·Neurotoxicity Research·Beatrice FerrariMaria Grazia Bottone
May 10, 2018·Frontiers in Pharmacology·Spencer DunawayAna L Kadekaro
Mar 11, 2020·Pharmacological Reports : PR·Mohammad SoukhtanlooAmir R Afshari
Feb 19, 2021·Medical Oncology·Ceyhan HaciogluGungor Kanbak
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Saleh A AlmatroodiArshad Husain Rahmani
May 3, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mariana MagalhãesCélia Cabral
Jul 16, 2021·Journal of Nanobiotechnology·Meng WangPeng Zhang