Quercetin derivatives regulate melanosome transportation via EPI64 inhibition and elongate the cell shape of B16 melanoma cells

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Kosei YamauchiTohru Suzuki

Abstract

4'-O-β-D-glucopyranosyl-quercetin-3-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranoside (3C4'GQ), first isolated from Helminthostachys zeylanica root extract, was synthesized as a compound that stimulates intracellular melanogenesis. 3-O-methylquercetin (3MQ) and 3,4',7-O-trimethylquercetin (34'7TMQ) were synthesized as compounds that enhance extracellular melanin formation. The formation of dendrites and the expression of EBP50-PDZ interactor of 64 kDa (EPI64) relating to melanin transportation were investigated using B16 melanoma cells treated with 3C4'GQ, 3MQ, or 34'7TMQ in order to understand the mechanism underlying the observed activities. The influence of 3C4'GQ on the increase of intracellular melanin contents enhanced the expression of EPI64, exhibited no dendrite elongation activity, and inhibited melanin transportation. On the other hand, the increase of extracellular melanin content by 3MQ and 34'7TMQ inhibited the expression of EPI64 and formed elongated cells to stimulate melanin transportation.

References

Feb 22, 1995·Biochimica Et Biophysica Acta·A Sánchez-FerrerF García-Carmona
Oct 29, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P C Hollman, M B Katan
Oct 5, 2001·Nature Reviews. Molecular Cell Biology·M S Marks, M C Seabra
Mar 12, 2002·Nature Cell Biology·Xufeng S WuJohn A Hammer
Jun 27, 2002·Journal of Agricultural and Food Chemistry·Qing-Xi Chen, Isao Kubo
Jul 16, 2003·Molecular and Cellular Biology·Taruho S KurodaMitsunori Fukuda
Aug 23, 2006·The Journal of Biological Chemistry·Takashi Itoh, Mitsunori Fukuda
May 1, 2009·Molecular Biology of the Cell·Kanako TamuraMitsunori Fukuda
Sep 8, 2009·Bioscience, Biotechnology, and Biochemistry·Takashi Fujii, Morio Saito
Jul 20, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yan YeZhi-Ling Yu
Feb 4, 2011·Phytotherapy Research : PTR·Yeon-Mi YangJeong-Chae Lee
Apr 3, 2012·Biochemical and Biophysical Research Communications·Haiying GuoTian Yang
Aug 2, 2013·Asian Pacific Journal of Tropical Biomedicine·Sang Suk KimChang-Gu Hyun
Jan 2, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hsiu-Mei ChiangKuo-Ching Wen
Jan 18, 2014·Bioorganic & Medicinal Chemistry·Kosei YamauchiIrmanida Batubara

❮ Previous
Next ❯

Citations

Feb 15, 2018·Journal of Natural Medicines·Kosei Yamauchi, Tohru Mitsunaga
Nov 17, 2019·Ageing Research Reviews·Barbara Bellei, Mauro Picardo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Glycosides

Cardiac glycosides are a diverse family of naturally derived compounds that bind to and inhibit na+/k+-atpase. Discover the latest research on cardiac glycosides heres.