PMID: 18424596Apr 22, 2008Paper

Quercetin from shallots (Allium cepa L. var. aggregatum) is more bioavailable than its glucosides

The Journal of Nutrition
Wieslaw WiczkowskiM K Piskula

Abstract

The lipophilic character of quercetin suggests that it can cross enterocyte membranes via simple diffusion. Therefore, it should be more bioavailable than its glucosides, which require preliminary hydrolysis or active transport for absorption. However, the published human studies show that quercetin is less bioavailable than its glucosides. Assuming that low bioavailability of quercetin aglycone provided to humans as a pure substance is the result of its low solubility in the digestive tract, we studied its bioavailability from dietary sources in which quercetin was dispersed in the food matrix. In a randomized crossover study, 9 volunteers took a single dose of either shallot flesh (99.2% quercetin glucosides and 0.8% quercetin aglycone) or dry shallot skin (83.3% quercetin aglycone and 16.7% quercetin glucosides), providing 1.4 mg quercetin per kg of body weight. Blood samples were collected before and after consumption of shallot preparations. Plasma quercetin was measured on HPLC with electrochemical detection after plasma enzymatic treatment. The maximum plasma quercetin concentration of 1.02 +/- 0.13 micromol/L was reached at 2.33 +/- 0.50 h after shallot flesh consumption compared with 3.95 +/- 0.62 micromol/L at 2.78 +/...Continue Reading

References

Dec 1, 1995·The American Journal of Clinical Nutrition·P C HollmanM B Katan
Jul 9, 1998·Free Radical Biology & Medicine·J M GeeI T Johnson
Nov 23, 2000·Journal of Agricultural and Food Chemistry·A NgK W Waldron
May 22, 2001·Journal of Clinical Pharmacology·E U GraefeM Veit
Jan 24, 2002·Journal of Agricultural and Food Chemistry·Vanessa CrespyChristian Remesy
Mar 7, 2002·Journal of Agricultural and Food Chemistry·Keiko AzumaJunji Terao
Mar 4, 2003·The Journal of Nutrition·Aloys L A SesinkPeter C H Hollman
Jun 3, 2004·The Journal of Nutrition·Stephanie LesserSiegfried Wolffram
Jan 11, 2005·The American Journal of Clinical Nutrition·Claudine ManachChristian Rémésy
Jan 11, 2005·The American Journal of Clinical Nutrition·Gary Williamson, Claudine Manach
Apr 19, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Brigitte A GrafChristine A Edwards

❮ Previous
Next ❯

Citations

Feb 7, 2014·Critical Reviews in Food Science and Nutrition·M R Pérez-GregorioD P F Almeida
Mar 3, 2015·Molecular Nutrition & Food Research·Wiesław WiczkowskiMariusz K Piskula
Mar 22, 2016·Nutrients·Yao LiYulong Yin
May 14, 2016·Bioscience, Biotechnology, and Biochemistry·Yanqing ZangYu Li
Jan 19, 2010·Pharmaceuticals·Abigail J LarsonThunder Jalili
Jul 18, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chi-Yu HeYan Wang
Aug 28, 2015·Molecular Nutrition & Food Research·Joseph A RothwellAugustin Scalbert
Jun 28, 2020·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Yuli Qian, John S Markowitz
Oct 2, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Stephan C Bischoff
Aug 25, 2012·Oxidative Medicine and Cellular Longevity·Garry Duthie, Philip Morrice
Sep 17, 2015·Journal of Food Science·Yasuaki KashinoJunji Terao
Jun 3, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Aik Jiang Lau, Thomas K H Chang
Apr 16, 2016·World Journal of Clinical Oncology·Guilherme di Camillo OrfaliDenise Gonçalves Priolli
Aug 25, 2016·Biomedical Chromatography : BMC·Khaled S AbdelkawyFawzy Elbarbry
Jan 5, 2019·Genes & Nutrition·Giulia PraticòLars O Dragsted
Dec 27, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yu-Feng YaoChen-Chen Zhu
May 30, 2020·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Morteza JafariniaNahid Eskandari
Sep 24, 2020·Antioxidants·Damini KothariSoo-Ki Kim
Jul 9, 2016·Preventive Nutrition and Food Science·Jeong-Yeon KoSang-Bin Lim
May 18, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jiri MlcekJiri Sochor
Oct 5, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lu WangZhenqiang Wu
Aug 22, 2013·Molecular Nutrition & Food Research·Ewa RomaszkoMariusz K Piskula
Jan 31, 2020·Journal of Cellular and Molecular Medicine·Tian HuShi-Jie Zhang
May 1, 2018·Comprehensive Reviews in Food Science and Food Safety·A Filipa AlmeidaCláudia N Santos
Jan 26, 2021·Oxidative Medicine and Cellular Longevity·Dengyu YangPeng Li
Mar 2, 2021·Pharmaceutical Biology·Narges MarefatiMohammad Hosein Boskabady
Oct 5, 2010·Journal of Agricultural and Food Chemistry·Hyun Ju YouGeun Eog Ji
Sep 13, 2018·Journal of Agricultural and Food Chemistry·Silvia WeinSiegfried Wolffram

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.