Quercetin lowers plasma uric acid in pre-hyperuricaemic males: a randomised, double-blinded, placebo-controlled, cross-over trial

The British Journal of Nutrition
Yuanlu Shi, Gary Williamson

Abstract

Elevated plasma uric acid concentration is a risk factor for gout, insulin resistance and type 2 diabetes. Quercetin, a flavonoid found in high levels in onions, tea and apples, inhibits xanthine oxidoreductase in vitro, the final step in intracellular uric acid production, indicating that quercetin might be able to lower blood uric acid in humans. We determined the effects of 4 weeks of oral supplementation of quercetin on plasma uric acid, blood pressure and fasting glucose. This randomised, double-blinded, placebo-controlled, cross-over trial recruited twenty-two healthy males (19-60 years) with baseline plasma uric acid concentration in the higher, but still considered healthy, range (339 (SD 51) µmol/l). The intervention included one tablet containing 500 mg quercetin daily for 4 weeks, compared with placebo, with a 4-week washout period between treatments. The primary outcome was change in concentrations of plasma uric acid after 2 and 4 weeks; secondary outcome measures were changes in fasting plasma glucose, 24-h urinary excretion of uric acid and resting blood pressure. After quercetin treatment, plasma uric acid concentrations were significantly lowered by -26·5 µmol/l (95% CI, -7·6, -45·5; P=0·008), without affecting...Continue Reading

References

Dec 4, 1991·JAMA : the Journal of the American Medical Association·F FacchiniG M Reaven
Mar 1, 1987·The American Journal of Medicine·E W CampionL O DeLabry
Apr 10, 1995·Archives of Internal Medicine·N R CookC H Hennekens
May 23, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·H M PrincenH Pijl
Oct 23, 1998·Journal of Epidemiology·M KimiraS Watanabe
Dec 19, 2000·Free Radical Biology & Medicine·A J DayG Williamson
Jun 11, 2002·Biochemical and Biophysical Research Communications·Chun-Mao LinJen-Kun Lin
Oct 17, 2002·JAMA : the Journal of the American Medical Association·Paul K WheltonUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Jan 14, 2005·Annals of the Rheumatic Diseases·T R MikulsK G Saag
Dec 13, 2005·The New England Journal of Medicine·Michael A BeckerNancy Joseph-Ridge
Dec 13, 2005·The New England Journal of Medicine·Larry W Moreland
Dec 15, 2006·Journal of the American Society of Nephrology : JASN·John P FormanGary C Curhan
Dec 28, 2006·Hypertension·Eswar KrishnanLewis Kuller
Aug 2, 2007·Biological & Pharmaceutical Bulletin·Shi-Fu MoLing-Dong Kong
Oct 9, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Soon Sun HongHyo-Kyung Han
Oct 24, 2007·The Journal of Nutrition·Randi L EdwardsThunder Jalili
Dec 20, 2007·Clinical Chemistry·Kuo-Liong ChienFrank B Hu
Feb 5, 2008·BMJ : British Medical Journal·Hyon K Choi, Gary Curhan
Jun 14, 2008·Nutrition·Agnes W BootsGuido R M M Haenen
Jun 19, 2008·Journal of Agricultural and Food Chemistry·Sylvain AuclairAugustin Scalbert
Aug 2, 2008·American Journal of Hypertension·Toshihiro HamadaIchiro Hisatome
Aug 22, 2008·The Journal of Nutrition·Sarah EgertManfred James Mueller
Aug 30, 2008·JAMA : the Journal of the American Medical Association·Daniel I FeigRichard J Johnson
Aug 21, 2009·Lancet·Pascal Richette, Thomas Bardin
Apr 7, 2010·Nature Reviews. Gastroenterology & Hepatology·Jung Sub LimRobert H Lustig
Apr 30, 2010·Database : the Journal of Biological Databases and Curation·V NeveuA Scalbert
Sep 9, 2010·Arthritis Care & Research·Peter C GraysonHyon K Choi
Oct 18, 2011·Seminars in Nephrology·Young Hee RhoHyon K Choi
Oct 18, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuo KansuiKiyoshi Matsumura
Nov 29, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M PfeufferJ Schrezenmeir
Apr 25, 2012·Obesity Surgery·Carlyne RemediosMuffazal Lakdawala
Aug 15, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·W-T LinC-H Lee
Nov 24, 2012·Current Pharmaceutical Design·Davide GrassiClaudio Ferri
Jan 26, 2013·Annals of the Rheumatic Diseases·Nicola DalbethTony R Merriman
Apr 8, 2014·Rheumatic Diseases Clinics of North America·Edward Roddy, Hyon K Choi
Apr 29, 2014·Biochemical and Biophysical Research Communications·Yuzhang ZhuJidong Cheng

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Citations

Aug 17, 2016·International Journal of Molecular Sciences·Thiago Melo Costa PereiraElisardo Corral Vasquez
Jan 20, 2017·Cytotechnology·Shin-Ichi AdachiKazumi Yagasaki
Nov 12, 2017·Molecular Nutrition & Food Research·Susanne AndresAlfonso Lampen
Jul 30, 2017·Molecular Nutrition & Food Research·Arrigo F G CiceroClaudio Borghi
Jul 12, 2018·Critical Reviews in Food Science and Nutrition·Hui CaoJianbo Xiao
Jun 5, 2019·International Journal of Molecular Sciences·Violetta MohosMiklós Poór
Nov 5, 2019·Critical Reviews in Food Science and Nutrition·Hande Gül Ulusoy, Nevin Sanlier
Oct 11, 2019·International Journal of Molecular Sciences·Mohammad Hosein FarzaeiAnupam Bishayee
Dec 21, 2018·Current Medicinal Chemistry·Manuel SánchezJuan Duarte
Aug 17, 2020·Expert Opinion on Therapeutic Patents·Jatinder Vir SinghSahil Sharma
Jun 18, 2019·Therapeutic Advances in Musculoskeletal Disease·Marcum W CollinsJasvinder A Singh
Jan 10, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Marcin OżarowskiAgnieszka Seremak-Mrozikiewicz
Feb 19, 2016·Molecular Nutrition & Food Research·Asimina Kerimi, Gary Williamson
Oct 7, 2017·Nutrition Bulletin·G Williamson
Jan 24, 2019·Nutrients·Ilenia BazzucchiFrancesco Felici
Sep 9, 2017·Journal of the Science of Food and Agriculture·Francesca OlivieroPaolo Spinella
Aug 25, 2019·Nutrients·Stefanos RoumeliotisVassilios Liakopoulos
Sep 23, 2020·Nutrients·Ilenia BazzucchiMassimo Sacchetti
Oct 18, 2020·Nutrients·Gary Williamson, Katherine Sheedy
Nov 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shin-Ichi AdachiKazumi Yagasaki
Sep 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Gary WilliamsonAlan Crozier
Apr 28, 2021·Critical Reviews in Food Science and Nutrition·Wing-Fu Lai, Wing-Tak Wong
Aug 6, 2021·Nutrition Research and Practice·Seo Young HongWookyoung Kim
Aug 10, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marjan TalebiSaeed Samarghandian
Aug 21, 2021·Frontiers in Cell and Developmental Biology·Zuqing SuYing Zhu

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