Quercetin prevents small intestinal damage and enhances intestinal recovery during methotrexate-induced intestinal mucositis of rats

Food & Nutrition Research
Igor SukhotnikBetty Schwartz

Abstract

Gastrointestinal mucositis occurs as a consequence of cytotoxic treatment. Quercetin (QCT) is a bioflavonoid that exerts significant antioxidant activity and anti-inflammatory as well as anti-malignancy properties. To evaluate the effects of oral QCT consumption in preventing intestinal mucosal damage and stimulating intestinal recovery following methotrexate (MTX)-induced intestinal damage in a rat model. Male Sprague-Dawley rats were divided into four groups: Control Group A (CONTR) - rats were treated with 2 cc of saline given by gavage for 6 days. Group B (CONTR-QCT) - rats were treated with QCT (100 mg/kg in 2 ml saline) given by gavage 3 days before and 3 days after intraperitoneal (IP) injection of saline. Group C (MTX) - rats were injected a single dose (25 mg/kg) of MTX IP. Group D (MTX-QCT) rats were treated with QCT (similar to Group B) 3 days before and 3 days after IP MTX injection. Intestinal mucosal parameters (bowel and mucosal weight, mucosal DNA and protein content, and villus height and crypt depth), enterocytes proliferation, and enterocyte apoptosis degree were investigated at sacrifice on the 4th day after MTX or saline injection. Administration of QCT to MTX-treated rats resulted in: (1) significant decre...Continue Reading

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Citations

Mar 30, 2019·Current Opinion in Supportive and Palliative Care·Hannah R WardillAndrea M Stringer
Mar 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lei SunWenfa Lu
Sep 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xianrong ZhouYan Zhang
Jun 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lázaro de Sousa FidelesGilberto Santos Cerqueira
Mar 13, 2021·Frontiers in Pharmacology·Ram BhartiNeeraj Khatri
Apr 21, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gurleen KourZabeer Ahmed
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Mervat A Abdel-LatifHatem S Abd El-Hamid

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Methods Mentioned

BETA
protein assay
light microscopy

Software Mentioned

Image Pro Plus
Prism
GraphPad

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