Quercetin reduces Ehrlich tumor-induced cancer pain in mice

Analytical Cellular Pathology (Amsterdam)
Cássia Calixto-CamposWaldiceu A Verri

Abstract

Cancer pain directly affects the patient's quality of life. We have previously demonstrated that the subcutaneous administration of the mammary adenocarcinoma known as Ehrlich tumor induces pain in mice. Several studies have shown that the flavonoid quercetin presents important biological effects, including anti-inflammatory, antioxidant, analgesic, and antitumor activity. Therefore, the analgesic effect and mechanisms of quercetin were evaluated in Ehrlich tumor-induced cancer pain in mice. Intraperitoneal (i.p.) treatments with quercetin reduced Ehrlich tumor-induced mechanical and thermal hyperalgesia, but not paw thickness or histological alterations, indicating an analgesic effect without affecting tumor growth. Regarding the analgesic mechanisms of quercetin, it inhibited the production of hyperalgesic cytokines IL-1β and TNFα and decreased neutrophil recruitment (myeloperoxidase activity) and oxidative stress. Naloxone (opioid receptor antagonist) inhibited quercetin analgesia without interfering with neutrophil recruitment, cytokine production, and oxidative stress. Importantly, cotreatment with morphine and quercetin at doses that were ineffective as single treatment reduced the nociceptive responses. Concluding, querc...Continue Reading

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Citations

May 17, 2017·Inflammopharmacology·Kenji W Ruiz-MiyazawaWaldiceu A Verri
Feb 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Camila R FerrazWaldiceu A Verri
Nov 4, 2020·Marine Drugs·Amanda Mara TelesMaria do Desterro Soares Brandão Nascimento
Dec 22, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Ho-Sung LeeDae-Yeon Lee
Feb 14, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li MaAi Li
Jun 15, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Daniele Nascimento GouveiaAdriana Gibara Guimarães

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

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