Quercitrin, the Main Compound in Wikstroemia indica , Mitigates Skin Lesions in a Mouse Model of 2,4-Dinitrochlorobenzene-Induced Contact Hypersensitivity

Evidence-based Complementary and Alternative Medicine : ECAM
Jonghwan JegalMin Hye Yang

Abstract

Hapten-induced contact hypersensitivity (CHS) is widely utilized to induce immune activation in animal models of allergic contact dermatitis. Our previous findings suggested that the 95% EtOH extract of Wikstroemia indica (L.) C. A. Mey. has antiallergic and anti-inflammatory effects in DNCB-treated CHS SKH-1 hairless mice. The aim of this study was to evaluate the protective effects of compounds isolated from the EtOAc fraction of W. indica in RBL-2H3 cells and 2,4-dinitrochlorobenzene- (DNCB-) induced CHS mice. Of eight compounds in W. indica, that is, umbelliferone, daphnoretin, wikstrocoumarin, (+)-syringaresinol, tricin, (+)-lariciresinol, erythro-guaiacylglycerol-β-coniferyl ether, and quercitrin, quercitrin exhibited the most antiallergic activity against antigen-induced β-hexosaminidase release and IL-4 mRNA expression, which are markers of degranulation in RBL-2H3 cells. After a 7-sensitizing period, 14 days of DNCB treatment with or without topical pimecrolimus (1%) or quercitrin (0.5%) treatment, quercitrin was found to suppress DNCB-induced increases in serum IL-4 and IgE concentrations and transepidermal water loss. These results indicate that quercitrin has therapeutic potential for treatment of allergies and alle...Continue Reading

References

Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J PunnonenJ E de Vries
Apr 14, 1999·The Journal of Investigative Dermatology·C TraidlN Hunzelmann
Jul 27, 1999·Life Sciences·G Di CarloF Capasso
Oct 26, 2001·Current Opinion in Immunology·G GirolomoniA Cavani
May 30, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Hideaki WatanabeDaniel N Sauder
Oct 21, 2004·Free Radical Research·Claudine Manach, Jennifer L Donovan
Mar 30, 2006·Nature Genetics·Thomas J Hudson
Jul 4, 2006·The Journal of Allergy and Clinical Immunology·Michael J CorkRachid Tazi-Ahnini
Mar 27, 2007·Allergology International : Official Journal of the Japanese Society of Allergology·Mari KawaiToshio Tanaka
Jan 3, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·R DarlenskiJ W Fluhr
Mar 21, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Egle PassanteNeil Frankish
May 16, 2009·Journal of Pharmaceutical and Biomedical Analysis·Montserrat DueñasCelestino Santos-Buelga
Aug 12, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Egle Passante, Neil Frankish
Nov 26, 2009·The Journal of Allergy and Clinical Immunology·Luz S FonacierDonald Y M Leung
Mar 19, 2011·Veterinary Dermatology·Rosanna MarsellaUNKNOWN International Task Force on Canine Atopic Dermatitis
Jun 21, 2011·Immunological Reviews·Mark Boguniewicz, Donald Y M Leung
Aug 11, 2011·Recent Patents on Inflammation & Allergy Drug Discovery·Laura MarzocchellaRoberto Bei
Dec 14, 2011·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Anne Deen Christensen, Claus Haase
Jan 13, 2012·Pharmaceutical Biology·Chuan-Li LuJian-Guo Jiang
Jan 19, 2012·Nutrients·Rong Tsao
Apr 18, 2012·Clinics in Dermatology·Adone BaroniRonni Wolf
Aug 31, 2012·The Journal of Investigative Dermatology·Tetsuya HondaKenji Kabashima
Oct 13, 2012·Frontiers in Plant Science·María L Falcone FerreyraPaula Casati
May 29, 2013·Allergology International : Official Journal of the Japanese Society of Allergology·Donald Y M Leung
Jan 15, 2015·The Journal of Allergy and Clinical Immunology·Joel Correa da RosaEmma Guttman-Yassky
Feb 26, 2016·Drug Discovery Today·Vengadeshprabhu KaruppagounderKenichi Watanabe
Oct 21, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jin Kyeong ChoiSang-Hyun Kim

❮ Previous
Next ❯

Citations

Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jimena BorgoValeria P Sülsen

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

7500 System SDS

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.