Quercus ilex pollen allergen, Que i 1, responsible for pollen food allergy syndrome caused by fruits in Spanish allergic patients.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
María PedrosaRosa Rodriguez-Perez

Abstract

Pollen food allergy syndrome (PFAS) related to PR10 from vegetables is common in northern Europe, whereas in Mediterranean countries PFAS has been preferentially associated with profilins. However, there are pollen-allergic patients reactive to Bet v 1 in birch-free regions. Since it cannot be the primary sensitizer, there has to be another culprit. Quercus ilex is a good candidate as it belongs to the order Fagales. This order includes trees with highly sensitizing pollen such as alder, hazel, hornbeam, oak and chestnut because of the presence of PR10 allergens. PR10 allergens have indeed been described in other Quercus species. Our goals were to determine the rate of sensitization to Q. ilex in central Spain and the associated frequency of PFAS; secondly to identify and clone the Q. ilex allergen PR10. We included 224 allergic patients with respiratory symptoms to estimate the rate of sensitization. A skin prick test (SPT) and ImmunoCAP were performed. A total of 38 Q. ilex-sensitized patients were tested using Western blotting to determine the rate of Que i 1. Peptides from Que i 1 were analysed by MALDI-TOF/TOF and Orbitrap LC-MSMS. The Que i 1 sequence was first obtained from the Holm oak transcriptome then cloned and expr...Continue Reading

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Citations

Mar 27, 2021·Expert Review of Proteomics·J V Jorrin Novo
Apr 23, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Robert J Boyle, Mohamed H Shamji
Apr 26, 2021·Allergy·Kyoung Yong JeongJung-Won Park
May 19, 2021·Journal of Clinical Laboratory Analysis·Kyoung Yong JeongJung-Won Park
Nov 10, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Robert J Boyle, Mohamed H Shamji
Dec 18, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Javier SubizaNarganes Mj

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