Questionability of the benefits of routine laparotomy as the surgical approach for pheochromocytomas and abdominal paragangliomas

Surgery
F N PattouC A Proye

Abstract

Improvement of preoperative imaging of pheochromocytomas and abdominal paragangliomas may render routine laparotomy questionable as the surgical approach of choice for these lesions. We studied the records of 100 patients with chromaffin tumors who underwent abdominal exploration. The disease was familial in 28 patients and was malignant in 19. Seventy-five patients had intraadrenal disease (bilateral in 13). Computed tomography (CT), metaiodobenzylguanidine (MIBG) scintigraphy, and magnetic resonance imaging (MRI) were performed since 1979, 1984, and 1987 in 97, 73, and 43 patients, respectively. False-positive and false-negative results were defined as any discrepancy between imaging results and surgical findings. Overall accuracy of preoperative localization was 85% with CT scan, 77% with MIBG scintigraphy, and 86% with MRI. In unilateral pheochromocytoma, accuracy was 94% with CT scan, 80% with MIBG scintigraphy, and 96% with MRI. When all three studies were performed (n = 38), overall accuracy was 97% and only one extraadrenal tumor in a patient with familial pheochromocytoma was overlooked. The outstanding accuracy of available imaging techniques questions the strategy of routine laparotomy for sporadic and seemingly beni...Continue Reading

References

Mar 1, 1986·Journal of Computer Assisted Tomography·T H FalkeA E James
May 1, 1995·Archives of Surgery·R A Prinz
Mar 1, 1994·Clinical Nuclear Medicine·J BathmannE Moser
Nov 18, 1993·The New England Journal of Medicine·H P NeumannG Kirste

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Citations

Jul 5, 2002·World Journal of Surgery·Frits J BerendsH Jaap Bonjer
May 29, 2000·American Journal of Surgery·C Y LoK S Lam
Jul 11, 2003·Annales de chirurgie·S CherkiJ L Peix
Jan 26, 2002·European Journal of Radiology·Amir KurtaranBrahm Shapiro
Feb 25, 1999·The Australian and New Zealand Journal of Surgery·C A Proye, H H Nguyen
Jun 3, 1999·The Australian and New Zealand Journal of Surgery·H H NguyenD Huglo
May 1, 2002·Annals of Surgery·L Michael BruntJeffrey F Moley
May 25, 2001·AJR. American Journal of Roentgenology·S ChaoP J Slanetz
Apr 5, 2001·Surgical Endoscopy·E MiralliéY Héloury
Dec 5, 2006·Current Opinion in Urology·Gertraud Heinz-PeerBruno Niederle
Oct 3, 2001·BMC Surgery·B EdwinE Fosse
Dec 10, 2003·Mayo Clinic Proceedings·Dawn E JaroszewskiRonald A Hinder
Apr 27, 2004·Surgical Endoscopy·A M KazaryanB Edwin

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