Abstract
Opioid-induced hyperalgesia has been demonstrated in awake animals. We observed an increased haemodynamic reactivity in response to noxious stimuli in rats under sevoflurane anaesthesia treated with a very low dose of sufentanil. The aim of this investigation was to determine whether the two phenomena share a common origin: an opioid-induced excitatory reaction. To address this, we administered several drugs with proven efficacy in opioid hyperalgesia to rats presenting with haemodynamic hyper-reactivity. The MACbar of sevoflurane was measured in controls and in animals treated with sufentanil 0.005 micro g kg(-1) min(-1) before and after administration of i.v. (0.25, 0.5 mg kg(-1)) and intrathecal (i.t.) (250 micro g) ketamine, i.v. (0.5, 1 mg kg(-1)) and i.t. (30 micro g) MK-801(NMDA antagonist), i.v. (0.1, 0.5 mg kg(-1)) naloxone, i.v. (10 mg kg(-1)) and i.t. (50, 100 micro g) ketorolac or i.t. (100, 150 micro g) meloxicam (COX-2 inhibitor). Sufentanil 0.005 micro g kg(-1) min(-1) significantly increased MACbar (3.2 (sd 0.3) versus 1.9 (0.3) vol%). With the exception of naloxone, all drugs displayed a significant MACbar-sparing effect (>50%) in controls. Naloxone completely prevented haemodynamic hyperactivity. Two patterns ...Continue Reading
References
Jul 1, 1992·The Annals of Pharmacotherapy·J T MossS Sayson
Nov 1, 1965·Anesthesiology·E I EgerB Brandstater
Jan 1, 1983·The Journal of International Medical Research·J C Devoghel
Mar 10, 1980·Life Sciences·D J SmithB Coalgate
Jan 1, 1982·Pain·G M Pekoe, D J Smith
May 1, 1981·Anesthesiology·M F RoizenB M Frazer
Aug 1, 1995·British Journal of Anaesthesia·A H Dickenson
Nov 1, 1995·British Journal of Anaesthesia·K IshizakiT Fujita
Apr 14, 1995·Neuroscience Letters·J Feng, J J Kendig
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·W E KaufmannP Isakson
Dec 1, 1995·Pharmacology & Toxicology·O HustveitI Oye
Jan 1, 1996·Drugs·J N Cashman
Nov 11, 1996·Brain Research·T Yamamoto, N Nozaki-Taguchi
Nov 14, 1997·General Pharmacology·Y MaruokaM Nakamura
Nov 24, 1998·Brain Research·M L SotgiuP Marchettini
Feb 10, 2000·Pain·S M Crain, K F Shen
Feb 26, 2000·Anesthesiology·E CélèrierG Simonnet
Jan 9, 2001·Brain Research·S M Crain, K F Shen
Jan 31, 2002·Anesthesiology·Cyril RivatGuy Simonnet
Jun 18, 2002·British Journal of Anaesthesia·R NadesonC S Goodchild
Jun 29, 2002·Anesthesia and Analgesia·Bruno GuignardMarcel Chauvin
Sep 23, 2003·Anesthesia and Analgesia·Marie-Agnes DocquierMarc De Kock
Citations
Mar 2, 2006·Anesthesiology·Martin S Angst, J David Clark
Jun 3, 2009·European Journal of Anaesthesiology·Patrice ForgetMarc De Kock
Apr 19, 2008·Anesthesia and Analgesia·Frédéric AubrunBruno Riou
Jun 2, 2011·Veterinary Anaesthesia and Analgesia·Lydia LoveThomas Doherty
Sep 28, 2020·Journal of Clinical Pharmacy and Therapeutics·Changchun ChenFaping Tu
Oct 21, 2018·Neuroscience·Dionéia AraldiJon D Levine
Sep 1, 2009·Annales Françaises D'anesthèsie Et De Rèanimation·P Forget, M De Kock