Questioning the cardiocirculatory excitatory effects of opioids under volatile anaesthesia

British Journal of Anaesthesia
M-A DocquierM De Kock

Abstract

Opioid-induced hyperalgesia has been demonstrated in awake animals. We observed an increased haemodynamic reactivity in response to noxious stimuli in rats under sevoflurane anaesthesia treated with a very low dose of sufentanil. The aim of this investigation was to determine whether the two phenomena share a common origin: an opioid-induced excitatory reaction. To address this, we administered several drugs with proven efficacy in opioid hyperalgesia to rats presenting with haemodynamic hyper-reactivity. The MACbar of sevoflurane was measured in controls and in animals treated with sufentanil 0.005 micro g kg(-1) min(-1) before and after administration of i.v. (0.25, 0.5 mg kg(-1)) and intrathecal (i.t.) (250 micro g) ketamine, i.v. (0.5, 1 mg kg(-1)) and i.t. (30 micro g) MK-801(NMDA antagonist), i.v. (0.1, 0.5 mg kg(-1)) naloxone, i.v. (10 mg kg(-1)) and i.t. (50, 100 micro g) ketorolac or i.t. (100, 150 micro g) meloxicam (COX-2 inhibitor). Sufentanil 0.005 micro g kg(-1) min(-1) significantly increased MACbar (3.2 (sd 0.3) versus 1.9 (0.3) vol%). With the exception of naloxone, all drugs displayed a significant MACbar-sparing effect (>50%) in controls. Naloxone completely prevented haemodynamic hyperactivity. Two patterns ...Continue Reading

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Citations

Mar 2, 2006·Anesthesiology·Martin S Angst, J David Clark
Apr 19, 2008·Anesthesia and Analgesia·Frédéric AubrunBruno Riou
Jun 2, 2011·Veterinary Anaesthesia and Analgesia·Lydia LoveThomas Doherty
Sep 28, 2020·Journal of Clinical Pharmacy and Therapeutics·Changchun ChenFaping Tu

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