Questionnaire-based case finding of celiac disease in a population of 8- to 9-year-old children

Pediatrics
Peter ToftedalSteffen Husby

Abstract

Antibody screenings and diagnosis of celiac disease (CD) among children with type 1 diabetes have suggested that a considerable proportion of children with CD may, in fact, have preclinical (undiagnosed) symptoms. We aimed to test if a questionnaire would lead to significant case finding in an unselected population of 8- to 9-year-old children. The study population included 9880 children aged 8 to 9 years. Before the study, 13 children from the study population were known to have CD. We developed a questionnaire on the basis of 5 simple items suggestive of CD and mailed the questionnaire to the families of all children in the study population who resided in the County of Funen, Denmark. In total, 7029 respondents returned the questionnaire (70%); among them, 2835 children had 1 or more symptoms. These children were invited for a blood test to determine their human serum immunoglobulin A (IgA) anti-tissue transglutaminase antibody (anti-tTG) levels. Of the 1720 children who were tested for the human serum IgA anti-tTG, 24 participants had a positive result (range: 20 to >150 U). Seventeen of these children underwent an upper endoscopy procedure. Fourteen children had histologic signs of CD (Marsh classification stage III). Fourt...Continue Reading

Citations

Jun 11, 2015·Best Practice & Research. Clinical Gastroenterology·M Luisa Mearin
Sep 27, 2019·Frontiers in Pediatrics·Alina Popp, Markku Mäki
Oct 13, 2018·Digestive Diseases and Sciences·Omer Faruk BeserUNKNOWN Northern Cyprus Celiac Study Group
Jul 30, 2018·International Archives of Allergy and Immunology·Lyudmila V SavvateevaAndrey A Zamyatnin

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