Quetiapine Attenuates the Neuroinflammation and Executive Function Deficit in Streptozotocin-Induced Diabetic Mice

Mediators of Inflammation
Kexin WangYu Sun

Abstract

Diabetic patients are at increased risk for developing memory and cognitive deficit. Prior studies indicate that neuroinflammation might be one important underlying mechanism responsible for this deficit. Quetiapine (QTP) reportedly exerts a significant neuroprotective effect in animal and human studies. Here, we investigated whether QTP could prevent memory deterioration and cognitive impairment in a streptozotocin- (STZ-) induced diabetic mouse model. In this study, we found that STZ significantly compromised the behavioral performance of mice in a puzzle box test, but administering QTP effectively attenuated this behavioral deficit. Moreover, our results showed that QTP could significantly inhibit the activation of astrocytes and microglia in these diabetic mice and reduce the generation and release of two cytokines, tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein-1 (MCP-1). Meanwhile, QTP also prevented the protein loss of the synaptic protein synaptophysin (SYP) and myelin basic protein (MBP). Here, our results indicate that QTP could inhibit neuroinflammatory response from glial cells and block the injury of released cytokines to neurons and oligodendrocytes in diabetic mice (DM). These beneficial eff...Continue Reading

References

Aug 1, 1997·Journal of Neuropathology and Experimental Neurology·C I SzeL J Martin
Sep 29, 2004·Diabetes Care·Wolfgang Rathmann, Guido Giani
Sep 30, 2004·Journal of Cognitive Neuroscience·Zoltan NagyTorkel Klingberg
Oct 11, 2005·Neurobiology of Aging·Christopher M Ryan
Nov 15, 2006·Archives of Neurology·Abimbola AkomolafeSudha Seshadri
Feb 24, 2007·Current Alzheimer Research·Kate X ZhongN A Devine
Apr 26, 2008·Endocrine Reviews·Christopher T Kodl, Elizabeth R Seaquist
Jul 4, 2009·Psychopharmacology·Satoshi YamamuraMotohiro Okada
Oct 27, 2011·Indian Journal of Endocrinology and Metabolism·Yatan Pal Singh Balhara
Jun 30, 2012·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·Andrea C SartoriMichael Crowe
Sep 13, 2014·Oxidative Medicine and Cellular Longevity·María MuriachJorge M Barcia
Nov 10, 2015·Brain, Behavior, and Immunity·Masahiro OhgidaniShigenobu Kanba
Jul 28, 2016·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Brianne M BettcherJoel H Kramer
Feb 9, 2017·Journal of Neuropathology and Experimental Neurology·Viktoria GudiThomas Skripuletz
Sep 12, 2017·Drug and Alcohol Dependence·Ryan K BachtellSandra D Comer

❮ Previous
Next ❯

Citations

Jul 3, 2019·International Journal of Molecular Sciences·Hidetoshi KomatsuYugo Habata

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
ELISA

Related Concepts

Related Feeds

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.