Quetiapine mitigates the neuroinflammation and oligodendrocyte loss in the brain of C57BL/6 mouse following cuprizone exposure for one week

European Journal of Pharmacology
Yuan ShaoHaiyun Xu

Abstract

This study aimed at examining effects of quetiapine (QTP), an atypical antipsychotic, on the behaviors of mice which had consumed cuprizone (CPZ)-containing diet for one week and on inflammatory reactions and oligodendrocyte (OL) loss in brains of them. Young adult C57BL/6 mice, after fed CPZ-containing diet (0.2%, w/w) for one week, showed an increase in the locomotor activity in the open-field, and a decreased exploration time in the novel object recognition (NOR) test compared to controls. But, these changes were not seen in mice co-administered with QTP and CPZ. All mice in the four groups showed comparable performances in Y-maze test. After the behavioral tests, mice were killed and their brains were processed for immunohistochemical and immunofluorescence staining to examine OLs, astrocytes and microglia. The levels of proinflammatory cytokines TNF-α and IL-6 in certain brain regions were also evaluated by ELISA method. Mice in the NS+CPZ group showed fewer OLs, more activated astrocytes and microglia with higher immunofluorescence intensity in the examined brain regions of the corpus callosum, caudate putamen, cerebral cortex, and hippocampus. The levels of TNF-α and IL-6 in some of these brain regions were also increase...Continue Reading

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Citations

Nov 2, 2016·Psychiatry and Clinical Neurosciences·Ekaterina SigitovaJiří Raboch
Aug 3, 2018·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jinling ZhangHaiyun Xu
Apr 16, 2020·Frontiers in Psychiatry·Natalya A UranovaDiana D Orlovskaya
Feb 16, 2020·European Archives of Psychiatry and Clinical Neuroscience·Natalya S Kolomeets, Natalya A Uranova
May 7, 2020·Genes, Brain, and Behavior·Maksym V KopanitsaAntti Nurmi
Aug 24, 2019·Neuroscience and Biobehavioral Reviews·Monokesh K SenPeter J Shortland
Feb 28, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sidhant ChopraPatrick McGorry
Jul 7, 2021·Journal of Cellular Biochemistry·Purushoth EthirajSakamuri V Reddy

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