PMID: 15385830Sep 24, 2004Paper

Quetiapine serum concentrations in psychiatric patients: the influence of comedication

Therapeutic Drug Monitoring
Jørgen Hasselstrøm, Kristian Linnet

Abstract

Steady-state serum concentrations of quetiapine were recorded in 62 psychiatric patients under routine conditions. Doses were administered twice daily, and serum quetiapine levels were measured in the morning about 12 hours after the last dose. Eight patients were in monotherapy, whereas the rest received various additional psychotropic drugs. For the whole group, the concentration-to-dose ratio (C/D) varied 238-fold, with a median value of 0.41 nmol/L/(mg/24 h). For the administered dose range (37.5-1200 mg/24 h), the serum concentrations ranged from below the detection limit (10 nmol/L) to 999 nmol/L. With the exception of 2 subjects receiving carbamazepine and patients receiving quetiapine outside the recommended dose interval, 80% of the rest had serum levels within the range 50 to 650 nmol/L, which may serve as an orienting interval for serum concentrations observed under routine treatment conditions. Patients (n = 38) comedicated with drugs competing for metabolism by CYP3A4 displayed a median C/D value of 0.48 nmol/L/(mg/24 h), which was 70% higher than the C/D value of the monotherapy group [0.28 nmol/L/(mg/24 h)], in contrast to patients receiving drugs metabolized by CYP2D6 with a median C/D of 0.23 nmol/L/(mg/24 h). ...Continue Reading

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Citations

Jul 17, 2007·Journal of Clinical Psychopharmacology·Benedikt HabermeyerFranz Müller-Spahn
Jan 20, 2006·International Clinical Psychopharmacology·Wolfgang AichhornGeorg Kemmler
May 28, 2009·Clinical Neuropharmacology·Thomas Nickl-JockschatMichael Grözinger
Jul 18, 2006·Drug Metabolism and Drug Interactions·Jørgen Hasselstrøm, Kristian Linnet
Sep 19, 2009·Pharmacogenomics·Sara HaackJulia Kirchheiner
Feb 16, 2012·Expert Opinion on Drug Metabolism & Toxicology·Jose de LeonEdoardo Spina
Nov 15, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Florian EyerThomas Zilker
Feb 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Edoardo SpinaJose de Leon
Feb 16, 2016·Expert Opinion on Drug Metabolism & Toxicology·Edoardo SpinaJose de Leon
Oct 18, 2016·Drug Safety - Case Reports·S GibiinoD De Ronchi
Jan 14, 2012·Biomedical Chromatography : BMC·Danielle S FisherRobert J Flanagan
Jul 15, 2015·Journal of Analytical Toxicology·Louise SkovKristian Linnet
Jan 1, 2007·International Journal of Psychiatry in Clinical Practice·Yves Le Bloc'hDaniele F Zullino
Oct 25, 2014·Journal of Analytical Toxicology·Louise SkovKristian Linnet
Sep 8, 2005·Psychosomatics·Neil B SandsonKelly L Cozza
Oct 30, 2013·Therapeutic Advances in Psychopharmacology·Simon A HandleyRobert J Flanagan
Apr 22, 2006·Therapeutic Drug Monitoring·N G M HunfeldD J Touw
Feb 15, 2014·Journal of Clinical Psychopharmacology·Karen van der Weide, Jan van der Weide
Nov 15, 2012·Therapeutic Drug Monitoring·Lisbeth PatteetHugo Neels
Jul 1, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Wolfgang AichhornJosef Marksteiner
Jun 20, 2018·Clinical Pharmacokinetics·Massimo Carlo MauriAlfredo Carlo Altamura
Feb 6, 2020·The Journal of Pharmacy and Pharmacology·Raj K S Badhan, Hannah Macfarlane

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