Quick and Easy Screening for Vitamin D Insufficiency in Adults: A Scoring System to Be Implemented in Daily Clinical Practice

Medicine
Mélanie DeschasauxMathilde Touvier

Abstract

Vitamin D is essential regarding several health outcomes. Prevention of insufficiency (25-hydroxyvitamin D concentration ≤20 ng/mL) generally entails blood testing and/or supplementation, strategies that should target at-risk individuals because blood testing is costly, and unwarranted supplementation could result in vitamin D overload with unknown long-term consequences. Our objective was to develop a simple score (Vitamin D Insufficiency Prediction score, VDIP) for identifying adults at risk of vitamin D insufficiency. Subjects were 1557 non-vitamin D-supplemented middle-aged adults from the SU.VI.MAX cohort. Scoring points corresponded to the rounded odds ratio for each individual-level characteristic associated with vitamin D insufficiency in a multivariable logistic regression model. Receiver operating characteristic curve (area under curve), sensitivity, specificity, and positive and negative predictive values were computed. External validation was performed in an independent cohort (NutriNet-Santé, N = 781). For female sex, overweight, low physical activity, winter season, moderate sun exposure, and very fair or dark skin 1.5 points were attributed; 2 points for latitude ≥48°N and spring season; 2.5 points for obesity an...Continue Reading

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Citations

Nov 16, 2016·Nutrients·Mélanie DeschasauxMathilde Touvier
Apr 17, 2018·Nutrients·Michelle RockwellJohn Epling
Jan 8, 2020·European Journal of Clinical Nutrition·Barbara AltieriMichael F Holick
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Methods Mentioned

BETA
blood draw
blood draws

Clinical Trials Mentioned

NCT00272428

Software Mentioned

SAS

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