Quick and Sensitive Enantioselective Determination of Permethrin in Fruits and Vegetables by Combining Supramolecular Solvents and Chiral Liquid Chromatography-Tandem Mass Spectrometry.

Journal of Agricultural and Food Chemistry
Ana Belén LaraSoledad Rubio

Abstract

Permethrin (PM) is one of the chiral insecticides most widely used around the world. The significant differential toxicity of its four enantiomers and its important adverse effects on human health highlights the need for determination of PM enantiomers. The aim of this work was to develop the first enantioselective method for quantification of PM in fruits and vegetables. The method is based on the extraction of PM enantiomers in supramolecular solvents with restricted access properties (SUPRAS-RAM) and their separation/detection by chiral liquid chromatography-tandem mass spectrometry (LC-MS/MS) which is first reported in this article. SUPRAS-RAM-based extraction is proposed as an innovative treatment approach that drastically reduces solvent consumption and avoids the need for sample cleanup. Extraction of PM enantiomers is quick (vortexing for 5 min) and efficient (recoveries 93-107%). The method is sensitive (quantification limits from 1.0 to 1.2 μg kg-1) and suitable for control of PM enantiomers in agri-food products.

References

Sep 20, 2000·Journal of Agricultural and Food Chemistry·G ShanB D Hammock
Sep 18, 2004·Journal of Agricultural and Food Chemistry·Eun-Kee ParkBruce D Hammock
Jul 6, 2006·Journal of Agricultural and Food Chemistry·Sujie QinJianying Gan
Nov 23, 2006·Journal of Agricultural and Food Chemistry·Sujie Qin, Jay Gan
Mar 19, 2009·Journal of Agricultural and Food Chemistry·Weiping LiuMeiqing Jin
Sep 15, 2010·Analytica Chimica Acta·Ana Ballesteros-GómezSoledad Rubio
Feb 3, 2015·Chemical Research in Toxicology·Jing YeWeiping Liu
May 18, 2016·Environmental Research·Xu WangZonghui Yuan
Oct 23, 2018·Medicina·Agnieszka ChrustekDorota Olszewska-Słonina

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