Quillaja saponin can modulate ovalbumin-induced IgE allergic responses through regulation of Th1/Th2 balance in a murine model

Journal of Agricultural and Food Chemistry
Shigeru Katayama, Yoshinori Mine

Abstract

Quillaja saponin is the extract from the balk of a South American tree, and it is considered to modulate immunological responses. We hypothesized that Quillaja saponin may change allergy-associated cytokine profile and antigen-specific immune responses. The purpose of this study is to investigate whether Quillaja saponin can suppress ovalbumin (OVA)-induced IgE-mediated allergic responses through promoting a dominant Th1 immune response. The spleen cells from BALB/c mice, which were primed by OVA, were used for an in vitro challenge test. The level of total and OVA-specific IgE, IL-4, IFN-gamma, and IL-12 was determined by enzyme-linked immunosorbent assay (ELISA). BALB/c mice were orally administered with saponin for 35 days. The mice were immunized intraperitoneally with OVA on days 14 and 21. After intraperitoneal challenge with OVA on day 35, anaphylactic symptoms were monitored. Total and specific IgE and IgG, specific IgG1 and IgG2a, and histamine levels in serum were analyzed by ELISA. The increase of IL-12 and IFN-gamma levels was observed in the presence of Quillaja saponin, while the IL-4 level was decreased. Furthermore, Quillaja saponin suppressed total and OVA-specific IgE secretion in spleen cells. Balb/c mice tha...Continue Reading

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Citations

Apr 11, 2007·Bioscience, Biotechnology, and Biochemistry·Hanae IzuMasato Hirotsune
Apr 29, 2014·Bulletin of Experimental Biology and Medicine·T A KuznetsovaL A Ten'kovskaya
Aug 31, 2014·International Immunopharmacology·Alok Kumar VermaPremendra D Dwivedi
Apr 29, 2008·Vaccine·Yoko ShojiVidadi Yusibov
Aug 12, 2014·Plant Foods for Human Nutrition·Alok Kumar VermaPremendra D Dwivedi
Oct 13, 2016·Bioscience, Biotechnology, and Biochemistry·Mamoru TanakaTakeaki Okamoto
May 29, 2009·The Journal of Nutrition·Bastiaan SchoutenLéon M J Knippels
Feb 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ntshepisa LebetwaShigeru Katayama
Jan 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juliane Deise FleckSimone Gasparin Verza
Jun 12, 2008·Journal of Agricultural and Food Chemistry·Yoshinori Mine, Marie Yang

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