Quinaprilat reduces myocardial infarct size involving nitric oxide production and mitochondrial KATP channel in rabbits

Journal of Cardiovascular Pharmacology
Xue-Hai ChenHisayoshi Fujiwara

Abstract

This study examined whether quinaprilat, an angiotensin-converting enzyme inhibitor, reduces the infarct size, and investigated the mechanisms for its infarct size-reducing effect, in rabbits. Japanese white rabbits underwent 30 min of ischemia and 48 h of reperfusion. Quinaprilat (100 microg/kg/h or 300 microg/kg/h for 70 min, IV) was administered 20 min before ischemia with or without pretreatment with Nomega-nitro-l-arginine methyl ester (l-NAME) (10 mg/kg, IV, a nitric oxide synthase inhibitor), 5-hydroxydecanoic acid sodium salt (5-HD) or posttreatment with 5-HD (5 mg/kg, IV, a mitochondrial KATP channel blocker). The area at risk as a percentage of the left ventricle was determined by Evans blue dye and the infarct size was determined as a percent of the area at risk by triphenyl tetrazolium chloride staining. Using a microdialysis technique, myocardial interstitial levels of 2,5-dihydroxybenzoic acid (2,5-DHBA), an indicator of hydroxyl radicals, and NOx, an indicator of nitric oxide, were measured before, during, and after 30 min of ischemia. Quinaprilat significantly reduced the infarct size in a dose-dependent manner (30.1 +/- 3%, n = 10, and 27.6 +/- 2%, n = 7, respectively) compared with the control (46.5 +/- 4%, n ...Continue Reading

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Citations

May 5, 2005·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Guillermo SchinellaSusana M Mosca
Mar 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Xuehai ChenHisayoshi Fujiwara
Dec 23, 2009·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Kanhei Charan SahooDharamvir Singh Arya
Mar 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Shinji YasudaShinya Minatoguchi
Mar 3, 2007·Pharmacological Reviews·Noboru TodaTomio Okamura
Aug 9, 2007·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Tatsuo IshizukaAkira Katsuki

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