PMID: 3753182Jan 1, 1986Paper

Quincke's edema in a dialysis patient after administration of acrylic bone cement: possible role of ethylene oxide allergy

Archives of Orthopaedic and Trauma Surgery
K W RumpfH J Sellin

Abstract

A 33-year-old female dialysis patient suffered from osteomyelitis and luxation of the dens axis with cervical myelopathy. In the past she had had three attacks of anaphylaxis after treatment with dialyzers that had been sterilized with ethylene oxide. IgE-type antibodies directed against human serum albumin-ethylene oxide complexes could be demonstrated in the patient's serum by radioallergosorbent techniques. Immediately after an operation in which acrylic bone cement (Palacos-R) sterilized with ethylene oxide was implanted for stabilization of the cervical spine, the patient developed massive edema of the larynx, pharynx, and tongue, suggesting Quincke's edema. It is concluded that ethylene oxide present in acrylic bone cement may induce acute allergic reactions in sensitized patients. Dialysis patients may be at special risk, since the incidence of ethylene oxide allergy in this patient population is about 10%.

References

Jan 1, 1975·Annals of Internal Medicine·J PoothullilJ Dolovich
Aug 1, 1984·Artificial Organs·W HenneG von Sengbusch

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Citations

Jun 1, 1987·Journal of Neurosurgery·J A PersingJ A Jane
Aug 3, 2010·ChemMedChem·Alexander Dömling, Kareem Khoury

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