PMID: 1204275Dec 1, 1975Paper

Quinine-induced alterations in drug disposition

Clinical Pharmacology and Therapeutics
C M BerlinE S Vesell

Abstract

In normal volunteers, chronic quinine administration shortened plasma antipyrine half-life and significantly increased the intraindividual correlation between the disposition of quinine and antipyrine. Decreased plasma antipyrine half-life appears to be due to a quinine-induced enhancement of antipyrine metabolism. A dose-dependent prolongation of plasma quinine half-life was observed and attributed primarily to an increased apparent volume of distribution of quinine, although our data did not permit separation of an effect on quinine metabolism from an effect on quinine distribution between the peripheral and central compartments. Plasma protein binding of quinine was similar at both the low and high doses of quinine. Studies in dogs given quinine intravenously revealed a biphasic plasma decay curve compatible with a 2-compartment open model for quinine disposition. Dose dependence of plasma quinine half-life in the dog after intravenous quinine eliminated altered gastrointestinal absorption of quinine as a cause for the dose dependence of plasma quinine half-life. These studies illustrate the importance of such conditions as dose and time of administration in determining the type and magnitude of interaction observed between ...Continue Reading

Citations

Aug 21, 1992·Pharmaceutisch Weekblad. Scientific Edition·C O OnyejiN C Ugwu
Sep 1, 1994·British Journal of Clinical Pharmacology·J R DyerJ Robson
Apr 7, 2015·The Cochrane Database of Systematic Reviews·Sherif El-TawilMarkus Weber
Apr 1, 1987·British Journal of Clinical Pharmacology·A WarburtonR J Dobbs
Jul 1, 1987·Medical Toxicology and Adverse Drug Experience·A JaegerF Flesch
Jul 1, 1990·Transactions of the Royal Society of Tropical Medicine and Hygiene·S M MansorM E Molyneux
Aug 17, 1977·European Journal of Clinical Pharmacology·P Bolme, U Otto
Nov 1, 1995·British Journal of Clinical Pharmacology·P AuprayoonJ Karbwang
Jan 1, 1990·The Journal of Pharmacy and Pharmacology·M D ColemanL Fleckenstein
Nov 1, 1982·British Journal of Clinical Pharmacology·B K Park
Jan 1, 1990·Pharmacology & Therapeutics·M Barry, J Feely

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