Quinine inhibits mitochondrial ATP-regulated potassium channel from bovine heart

The Journal of Membrane Biology
P BednarczykA Szewczyk

Abstract

The mitochondrial ATP-regulated potassium (mitoK(ATP) channel has been suggested as trigger and effector in myocardial ischemic preconditioning. However, molecular and pharmacological properties of the mitoK(ATP) channel remain unclear. In the present study, single-channel activity was measured after reconstitution of the inner mitochondrial membrane from bovine ventricular myocardium into bilayer lipid membrane. After incorporation, a potassium-selective current was recorded with mean conductance of 103 +/- 9 pS in symmetrical 150 mM KCl. Single-channel activity of this reconstituted protein showed properties of the mitoK(ATP) channel: it was blocked by 500 microM ATP/Mg, activated by the potassium-channel opener diazoxide at 30 microM, inhibited by 50 microM glibenclamide or 150 microM 5-hydroxydecanoic acid, and was not affected by the plasma membrane ATP-regulated potassium-channel blocker HMR1098 at 100 microM. We observed that the mitoK(ATP) channel was blocked by quinine in the micromolar concentration range. The inhibition by quinine was additionally verified with the use of 86Rb+ flux experiments and submitochondrial particles. Quinine inhibited binding of the sulfonylurea derivative [3H]glibenclamide to the inner mito...Continue Reading

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Citations

Nov 18, 2011·Pflügers Archiv : European journal of physiology·Ildikò SzabòMario Zoratti
Aug 1, 2008·Journal of Bioenergetics and Biomembranes·Piotr BednarczykAdam Szewczyk
Oct 13, 2009·Journal of Bioenergetics and Biomembranes·Katarzyna ChomaAdam Szewczyk
Jul 25, 2007·The Lancet Infectious Diseases·Nicholas J White
Apr 29, 2009·International Journal of Molecular Sciences·Jolanta SkalskaAdam Szewczyk
Feb 25, 2010·FEBS Letters·Adam SzewczykKrzysztof Dołowy
Mar 11, 2005·FEBS Letters·Piotr BednarczykAdam Szewczyk
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May 17, 2005·British Journal of Pharmacology·Jolanta SkalskaAdam Szewczyk
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Apr 26, 2007·Cellular & Molecular Biology Letters·Izabela Koszela-PiotrowskaKarol Ondrias
Sep 11, 2009·The Biochemical Journal·Izabela Koszela-PiotrowskaWieslawa Jarmuszkiewicz
Mar 13, 2012·Biochimica Et Biophysica Acta·Anna Kajma, Adam Szewczyk
Dec 30, 2008·Biochimica Et Biophysica Acta·Mario ZorattiIldikò Szabò
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Jan 11, 2021·Biochimica Et Biophysica Acta. Bioenergetics·Shane Austin, Karin Nowikovsky
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