PMID: 8600757Mar 1, 1996Paper

Quinine pharmacokinetics in young children with severe malaria

The American Journal of Tropical Medicine and Hygiene
M B van HensbroekP A Kager

Abstract

Children less than two years of age represent a substantial proportion of severe malaria cases in Africa. The standard treatment is parenteral quinine, but little is known about the pharmacokinetics and toxicity of quinine in this age group. We have studied the pharmacokinetics of quinine after intravenous (iv) and intramuscular (im) administration in a group of 20 children less then two years of age with severe malaria. A loading dose of 20 mg/kg of quinine dihydrochloride was followed by 10 mg/kg at 12-hr intervals. The im quinine was very rapidly absorbed, reaching high peak concentrations of 16.4 +/- 3.7 mg/L (mean +/- SD) in 1.1 +/- 0.4 hr. Mean peak levels after iv administration were also high (17.5 +/- 2.4 mg/L). Free quinine levels at 4 hr postadministration ranged from 0.27 to 1.89 mg/L (0.87 +/- 0.53 mg/L). At 2 hr and 4 hr after commencing treatment, an electrocardiogram showed a significant lengthening of the QRS interval compared with baseline (15.6 +/- 21.4%; P = 0.007 and 17.3 +/- 21.9%; P = 0.006 at 2 hr and 4 hr, respectively), whereas this was not observed in a control group of nine older children (age range = 24 months to 10 years) receiving the same im dosage regimen. Free and total quinine levels were not ...Continue Reading

Citations

Jul 10, 1998·Tropical Medicine & International Health : TM & IH·F A ClaessenP A Kager
May 17, 2001·Antimicrobial Agents and Chemotherapy·S KrishnaP W Stacpoole
Sep 13, 2014·Tropical Medicine & International Health : TM & IH
Nov 9, 2015·European Journal of Drug Metabolism and Pharmacokinetics·Iftekhar MahmoodRita Humeniuk
Jul 22, 2004·The Cochrane Database of Systematic Reviews·A Lesi, M Meremikwu
Jul 29, 2008·Tropical Medicine & International Health : TM & IH·Jacqueline L DeenArjen Dondorp
Jan 15, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·W Robert J Taylor, Nicholas J White
Mar 4, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·P E KofoedL Rombo
Apr 11, 2015·PloS One·Martin Kayitale MbonyeJean Pierre Van Geertruyden
Jun 6, 2000·The American Journal of Clinical Nutrition·F J RosalesA C Ross
Dec 1, 1996·Infectious Disease Clinics of North America·G S Murphy, E C Oldfield
Jun 9, 2009·Metabolism: Clinical and Experimental·Wilco C W R ZijlmansHans P Sauerwein

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