PMID: 15335195Sep 1, 2004Paper

Quinine-resistant severe falciparum malaria effectively treated with atovaquone and proguanil hydrochloride combination therapy

Internal Medicine
Hitoji UchiyamaNaoki Arizono

Abstract

A 22-year-old Japanese man noticed pyrexia and diarrhea after travel to Guinea. Notable physical findings included hepatosplenomegaly. Treatment with oral quinine and minocycline was started after definitive diagnosis of falciparum malaria by blood smear. Initially, parasitemia and body temperature decreased but by the third night of therapy his temperature increased to 40 degrees C with a slight increase of parasite count. When quinine treatment was changed to atovaquone/proguanil, his temperature dropped immediately and complete plasmodial elimination was confirmed on microscopic examination. Subsequent recrudescence of the disease was not observed. It was concluded that the antimalarial treatment with atovaquone/proguanil might become invaluable in Japan.

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Citations

Apr 28, 2006·Antimicrobial Agents and Chemotherapy·Willias MasochaKrister Kristensson
Jan 21, 2014·Journal of Molecular Graphics & Modelling·Brad Van OostenThad A Harroun
Jun 10, 2011·The Journal of Physical Chemistry. a·Dhilon S Patel, Prasad V Bharatam

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