Quinohemoprotein alcohol dehydrogenases: structure, function, and physiology

Archives of Biochemistry and Biophysics
Hirohide ToyamaKazunobu Matsushita

Abstract

Quino(hemo)protein alcohol dehydrogenases (ADH) that have pyrroloquinoline quinone (PQQ) as the prosthetic group are classified into 3 groups, types I, II, and III. Type I ADH is a simple quinoprotein having PQQ as the only prosthetic group, while type II and type III ADHs are quinohemoprotein having heme c as well as PQQ in the catalytic polypeptide. Type II ADH is a soluble periplasmic enzyme and is widely distributed in Proteobacteria such as Pseudomonas, Ralstonia, Comamonas, etc. In contrast, type III ADH is a membrane-bound enzyme working on the periplasmic surface solely in acetic acid bacteria. It consists of three subunits that comprise a quinohemoprotein catalytic subunit, a triheme cytochrome c subunit, and a third subunit of unknown function. The catalytic subunits of all the quino(hemo)protein ADHs have a common structural motif, a quinoprotein-specific superbarrel domain, where PQQ is deeply embedded in the center. In addition, in the type II and type III ADHs this subunit contains a unique heme c domain. Various type II ADHs each have a unique substrate specificity, accepting a wide variety of alcohols, as is discussed on the basis of recent X-ray crystallographic analyses. Electron transfer within both type II a...Continue Reading

Citations

Jul 11, 2009·Applied Microbiology and Biotechnology·Fusako Kawai, Xiaoping Hu
Aug 28, 2009·Applied Microbiology and Biotechnology·Watchara KanchanarachKazunobu Matsushita
Jun 14, 2013·Applied Microbiology and Biotechnology·Janja Trček, Kazunobu Matsushita
Aug 19, 2011·Molecular Plant-microbe Interactions : MPMI·Andrea KrauseBarbara Reinhold-Hurek
Jul 4, 2012·Applied and Environmental Microbiology·Muhammad Irfan ArifDick B Janssen
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Mar 7, 2008·International Journal of Food Microbiology·Saúl Gómez-ManzoEdgardo Escamilla-Marván
Jan 26, 2008·FEMS Microbiology Letters·Worrawat PromdenHirohide Toyama
Apr 25, 2019·International Journal of Molecular Sciences·Silke SchwarzGundula Schulze-Tanzil
Apr 14, 2012·Journal of Tissue Engineering and Regenerative Medicine·Márcia T RodriguesManuela E Gomes
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Oct 13, 2019·Applied and Environmental Microbiology·Kouta TakedaNobuhumi Nakamura

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