Quinoline-3-carboxamide derivatives as potential cholesteryl ester transfer protein inhibitors.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Wen-Yan LiJing-Kang Shen

Abstract

A series of novel quinoline-3-carboxamide derivatives 10-17 and 23-27 were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. All of them exhibited activity against CETP. Particularly, compounds 24 and 26 displayed the best activity against CETP with the same inhibitory rate of 80.1%.

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Citations

Feb 19, 2013·Bioorganic & Medicinal Chemistry Letters·Narsidas J ParmarNavin P Talpada
Aug 15, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·M Soledade C PedrasVijay K Sarma-Mamillapalle

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Methods Mentioned

BETA
column chromatography

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