Quinoline-derivative coordination compounds as potential applications to antibacterial and antineoplasic drugs

Materials Science & Engineering. C, Materials for Biological Applications
Camila Dos Santos ChagasIzilda A Bagatin

Abstract

Quinoline-derivative coordination compounds were synthesized with Zn(II), Al(III), Cu(II), Ru(II) producing 1-4 compounds using 5-nitro-8-hydroxyquinoline and 5-8 compounds using 5-chloro-8-hydroxyquinoline. These coordination compounds were characterized by elemental analysis and 1H NMR, IR, UV-Vis and fluorescence spectroscopies, representing the coherent data matched all compounds. Myelotoxicity data, as well as the biochemical data, depicted the compounds have low cytotoxicity towards the blood cells. All coordination compounds displayed slight antimicrobial activity against E. coli, S. aureus, P. aeruginosa and E. faecalis; [RuCl(NO)(5-chloro-8-oxyquinoline)2] compound (8) represent the best result to inhibitions of Gram-positive and Gram-negative bacteria. Antineoplasic action depicted the [Ru(NO)(5-nitro-8-oxyquinoline)2Cl] compound (4) as a potential chemotherapeutic agent against MCF-7 (a breast cancer cell line), compared to cisplatin (Platistine® CS) and cyclophosphamide (Genuxal®) drugs.

Citations

Nov 20, 2020·Archiv der Pharmazie·Atukuri Dorababu
Jan 30, 2021·Bioorganic Chemistry·Rohini GuptaKamaldeep Paul
Feb 24, 2021·Bioorganic Chemistry·Pratibha Yadav, Kamal Shah
May 29, 2021·Nucleosides, Nucleotides & Nucleic Acids·Bharat H PursuwaniMohan N Patel
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Željka SoldinZora Popović

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