PMID: 9435887Jan 1, 1997Paper

Quinoline-induced chromosome aberrations and sister chromatid exchanges in rat liver

Environmental and Molecular Mutagenesis
S AsakuraF Sagami

Abstract

Induction of chromosome aberrations and sister chromatid exchanges (SCEs) was studied in hepatocytes of F344 rats exposed in vivo to the hepatocarcinogen quinoline (Q). Hepatocytes were isolated 4-48 hr after a single dose of 200 mg/kg body weight or 24 hr after 28 repeated doses (once a day) of 25-200 mg/kg body weight/day by gastric intubation, and allowed to proliferate in Williams' medium E supplemented with epidermal growth factor. Cells were fixed after a culture period of 48 hr. A single dose of Q induced chromosome aberrations in up to 22% of metaphase cells, and SCEs with a frequency of up to 1.27 per chromosome 12 hr after the dose, while the control values were 1% and 0.63 per chromosome, respectively. Treatment with 28 repeated doses of Q induced significant chromosome aberrations and SCEs dose-dependently. Cytogenetic damage induced induced in the liver by repeated doses of Q was greater than induced by a single dose. Furthermore, Q induced replicative DNA synthesis in the liver, but failed to induce micronucleus formation in the bone marrow. The noncarcinogen 8-hydroxyquinoline was also examined and found to be essentially non-genotoxic to rat liver. These results show that Q is a genotoxic carcinogen to rat liver...Continue Reading

References

Jan 1, 1976·Methods in Cell Biology·P O Seglen
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Feb 1, 1991·Carcinogenesis·E J LaVoieC A McQueen
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Jan 1, 1989·Journal of Cancer Research and Clinical Oncology·S SawadaT Matsushima

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Citations

Apr 18, 2012·Toxicology and Applied Pharmacology·Astrid A ReusCyrille A M Krul
Jan 26, 2010·Journal of Hazardous Materials·Oscar RozasHéctor D Mansilla
Oct 10, 2013·Environmental Toxicology·Leidy Tatiana Díaz DuranJorge Luis Fuentes Lorenzo
Apr 22, 2015·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Fuyumi UnoMakoto Hayashi
Feb 27, 2018·The Journal of Toxicological Sciences·Michiharu MatsumotoShoji Fukushima

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