Quinolinic acid in tumors, hemorrhage and bacterial infections of the central nervous system in children

Journal of the Neurological Sciences
M P HeyesS J Schiff

Abstract

A potential mechanism that may contribute to neurological deficits following central nervous system infection in children was investigated. Quinolinic acid (QUIN) is a neurotoxic metabolite of the kynurenine pathway that accumulates within the central nervous system following immune activation. The present study determined whether the levels of QUIN are increased in the cerebrospinal fluid of children with infections of the CNS, hydrocephalus, tumors or hemorrhage. Extremely high QUIN concentrations were found in patients with bacterial infections or the CNS, despite treatment with antimicrobial agents. CSF QUIN levels were also elevated to a lesser degree in patients with hydrocephalus or tumors. CSF L-kynurenine levels increased in parallel to the accumulations in QUIN, which is consistent with increased activity of the first enzyme of the kynurenine pathway, indoleamine-2,3-dioxygenase. The CSF levels of neopterin, a marker of immune and macrophage activation, were also increase in patients with infections. The cytokines tumor necrosis factor-alpha and interleukin-6 were also detected in some patients' samples, and were highest in patients with infection. These results suggest that QUIN is a sensitive marker of the presence ...Continue Reading

References

Aug 1, 1976·American Journal of Diseases of Children·G M Hunt, A E Holmes
Aug 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M P HeyesJ H Vickers
May 1, 1992·The Biochemical Journal·M P HeyesS P Markey
Oct 1, 1991·Neurochemical Research·C Rios, A Santamaria
Jul 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J E Merrill, I S Chen
Nov 1, 1987·Neuroscience·J P Kim, D W Choi
Aug 1, 1987·The Pediatric Infectious Disease Journal·S H Sell
Nov 1, 1993·Annals of Neurology·M L BatshawM P Heyes
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·A MacayaR E Burke
Mar 1, 1994·Journal of Neuropathology and Experimental Neurology·D M RauschL E Eiden

❮ Previous
Next ❯

Citations

Feb 11, 1998·Molecular Neurobiology·D L Gruol, T E Nelson
Jan 11, 2005·Neurotoxicity Research·Gilles J GuilleminBruce J Brew
Apr 21, 1999·Life Sciences·S O HeyligerK F Soliman
Aug 11, 2000·Toxicon : Official Journal of the International Society on Toxinology·T W Stone
Sep 12, 2000·Free Radical Biology & Medicine·W E DaleO R Brown
Jan 10, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sophie ErhardtLena Brundin
Apr 13, 1999·Critical Care Medicine·D F Hanley
Apr 13, 1999·Critical Care Medicine·M J BellP D Adelson
Jun 17, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E H SinzD W Marion
Apr 23, 2004·Infection and Immunity·Rüdiger A AdamHorst Schroten
Aug 28, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Trevor W StoneL Gail Darlington
Mar 1, 2016·Neuropharmacology·Nicholas H HuntHelen J Ball
Sep 1, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·N Pérez VasquezF Moussa
Mar 24, 2000·Redox Report : Communications in Free Radical Research·S R Thomas, R Stocker
Apr 20, 2013·Brain, Behavior, and Immunity·Aye Mu MyintMarkus J Schwarz
Aug 5, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Csaba JuhászHarry T Chugani
Jun 8, 2017·Journal of Separation Science·Ilona SadokMagdalena Maria Staniszewska
Oct 9, 2019·Advanced Pharmaceutical Bulletin·Hridya JayamohanananAneesh T P
May 10, 2002·Annals of the New York Academy of Sciences·R Patarca
Apr 14, 2016·Metabolic Brain Disease·Cheng-Peng YuDa-Ya Luo
Jul 2, 2019·International Journal of Tryptophan Research : IJTR·Mona DehhaghiGilles J Guillemin
Dec 14, 2018·International Journal of Molecular Sciences·Fabíola Reis de OliveiraEduardo Melani Rocha
Jan 1, 2009·International Journal of Tryptophan Research : IJTR·Yiquan Chen, Gilles J Guillemin
Nov 13, 2012·Cancer Research·Seray AdamsGilles J Guillemin
Jun 2, 2021·The Journal of Surgical Research·Mohamad M MoughnyehColin A Martin
Nov 21, 2012·Journal of Proteome Research·Aifric O'SullivanCarolyn M Slupsky

❮ Previous
Next ❯

Related Concepts

Related Feeds

Central Nervous System Bacterial Infections

Central nervous system bacterial infections are medical emergencies and include bacterial meningitis and spinal epidural abscess. Treatment with antibiotics can reduce morbidity and mortality. Discover the latest research on central nervous system bacterial infections here.