PMID: 9449772Jan 1, 1996Paper

Quinolone effects in the SOS chromotest and the synthesis of biomacromolecules

Folia Microbiologica
L Majtánová, V Majtán

Abstract

The genotoxicity of quinolone antibiotics (ciprofloxacin, enoxacin, nalidixic acid, norfloxacin, ofloxacin, pefloxacin) was studied on the selected mutant E. coli strain PQ 37 (SOS chromotest). The genotoxicity was expressed by SOS-inducing potential (SOSIP) values. The highest SOSIP values were found with ciprofloxacin (SOSIP = 1967 delta IF/nmol), the lowest value was observed with nalidixic acid (SOSIP = 0.3 delta IF/nmol). Similar results were also found with the biosynthesis of nucleic acids, as indicated by incorporation of 14C-adenine into TCA-insoluble fractions of S. typhimurium cells (ciprofloxacin IC50 = 0.39, nalidixic acid IC50 = 400). DNA-damaging effects were tested in the absence of an exogenous metabolizing system.

References

Feb 1, 1992·Journal of Medical Microbiology·E G Power, I Phillips
Jan 1, 1990·Antimicrobial Agents and Chemotherapy·T D GootzJ A Sutcliffe
Jan 1, 1989·Environmental and Molecular Mutagenesis·B N Ames
Oct 1, 1989·Clinical Microbiology Reviews·J S Wolfson, D C Hooper
Jan 1, 1988·Reviews of Infectious Diseases·W ChristB Ulbrich
Jun 1, 1985·Mutation Research·P Quillardet, M Hofnung
Apr 1, 1967·Journal of Biochemistry·A Taketo, H Watanabe
Apr 1, 1993·Antimicrobial Agents and Chemotherapy·H YoshidaS Nakamura

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Citations

Mar 29, 2001·Folia Microbiologica·S JantováM Oravcová
Feb 24, 2004·Folia Microbiologica·V Majtán, L Majtánová
Aug 9, 2011·Expert Review of Anti-infective Therapy·Sheo B SinghLynn Miesel

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