PMID: 6537800Jan 1, 1984Paper

Quinone-induced DNA damage and its relationship to antitumor activity in L5178Y lymphoblasts

Cancer Research
A Begleiter, G W Blair

Abstract

The presence of a quinone group in the structure of a series of model compounds was shown to produce cell kill by a mechanism involving free radicals and active oxygen species. Furthermore, the ability of the compound to bind to DNA appeared to enhance its cytocidal activity. The same model compounds were used to investigate the effect of the quinone group on cellular DNA. DNA single-strand breaks, DNA double-strand breaks, and DNA-DNA cross-linking induced by the model compounds were measured by elution assays. Hydrolyzed benzoquinone mustard, which contains a quinone group, induced dose-dependent single-strand and double-strand breaks but no DNA cross-linking. Benzoquinone mustard, which possesses both a quinone moiety and an active alkylating group, produced dose-dependent DNA double-strand breaks but no apparent single-strand breaks. However, this compound produced significant levels of DNA cross-linking, a process which interferes with the assay for single-strand breaks. The relative activity of benzoquinone mustard in inducing DNA double-strand breaks was approximately 15,000-fold greater than that of hydrolyzed benzoquinone mustard. Aniline mustard, which has the same alkylating group as does benzoquinone mustard but no ...Continue Reading

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