Quinoxalinone as a Privileged Platform in Drug Development

Mini Reviews in Medicinal Chemistry
Leilei ShiXun Li

Abstract

Among the family of nitrogen-containing heterocycles, quinoxalinone (or quinoxalin-2-one) core, characterized by pyrazin-2(1H)-one fused to benzene ring at two adjacent carbon atoms, has been frequently found in a variety of pharmacologically active compounds with biological or pharmaceutical applications. It was gratifying that a larger part of these bioactive quinoxalinone-based derivatives has entered various clinical trials, which in turn hastens the synthetic versatility and also initiates various derivatization of quinoxalinone scaffold. In this review, we highlighted the newly emerged quinoxalinone- based derivatives or analogues, with the emphasis of their biological applications and structure-activity analysis covering literatures in recent years.

Citations

Mar 5, 2020·Chemical Communications : Chem Comm·Alberto F Garrido-CastroJosé Alemán
Aug 14, 2020·Organic & Biomolecular Chemistry·Hangcheng NiFei Zhao
Jul 14, 2018·Acta Crystallographica. Section E, Crystallographic Communications·Nicolas Chrysochos, Carola Schulzke
Sep 29, 2019·International Journal of Molecular Sciences·Chih-Hua TsengKai-Wei Tang
Jan 15, 2021·Bioorganic & Medicinal Chemistry Letters·Chang-Bo ZhengXun Li
Jan 2, 2020·European Journal of Medicinal Chemistry·Lucas FabianAlbertina Moglioni
Dec 3, 2021·Organic & Biomolecular Chemistry·Yi-Na LiZhen Wang

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