Quorum sensing: a new clinical target for Pseudomonas aeruginosa?

Médecine et maladies infectieuses
R Le BerreBenoit Guery

Abstract

Pseudomonas aeruginosa is an opportunistic bacteria causing a wide variety of infections. The bacterial virulence depends on a large panel of cell-associated and extracellular factors. Quorum sensing (QS) allows cell-to-cell communication: sensing the environment, this system coordinates the expression of various genes within the bacterial population. QS is based on an interaction between a small diffusible molecule, an acylhomoserine lactone (AHL), and a transcriptionnal activator. Two QS systems, the las and rhl systems, have been identified in P. aeruginosa. The las system associates the transcriptionnal activator protein LasR and LasI responsible for the synthesis of a specific AHL: C12-HSL. This system was shown to activate the expression of a large number of virulence factors. Similarly, the rhl system associates the transcriptionnal activator protein RhlR with RhlI, which is responsible for the synthesis of another AHL: C4-HSL. Synthesis and secretion of a number of virulence factors are controlled by QS. Utilization of different animals models showed the crucial role of QS in the pathogenesis of P. aeruginosa infections. The discovery of QS has given a new opportunity to treat bacterial infection by another means than g...Continue Reading

References

Nov 1, 1974·The Journal of Infectious Diseases·P V Liu
Oct 1, 1970·Journal of Bacteriology·K H NealsonJ W Hastings
Apr 28, 1981·Biochemistry·A EberhardN J Oppenheimer
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·J P PearsonE P Greenberg
Sep 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Y FagonC Gibert
May 1, 1997·Journal of Bacteriology·E C PesciB H Iglewski
Jun 1, 1997·Journal of Bacteriology·A M AlbusB H Iglewski
Nov 24, 1998·Infection and Immunity·G M DenningB E Britigan
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·M R ParsekE P Greenberg
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·E C PesciB H Iglewski
Apr 27, 2000·Journal of Bacteriology·S L McKnightE C Pesci
Sep 13, 2000·Nature·E P Greenberg
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·S A ChuganiE P Greenberg
May 17, 2001·Antimicrobial Agents and Chemotherapy·K TatedaC Van Delden
Jan 29, 2002·Nature Structural Biology·Stephen C Winans
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lynne R UsherMoira K B Whyte
Apr 6, 2002·American Journal of Respiratory and Critical Care Medicine·Jean Chastre, Jean-Yves Fagon
Apr 20, 2002·Current Opinion in Infectious Diseases·G P Bodey

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Citations

Oct 24, 2009·Médecine sciences : M/S·André DagenaisYves Berthiaume
Mar 23, 2011·PloS One·Scott CairnsDavid Wynne Williams
Mar 24, 2007·Microbiology·Freya Harrison

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