Quorum sensing inhibitors of Staphylococcus aureus from Italian medicinal plants.

Planta medica
Cassandra L QuaveBradley C Bennett

Abstract

Morbidity and mortality estimates due to methicillin-resistant Staphylococcus aureus (MRSA) infections continue to rise. Therapeutic options are limited by antibiotic resistance. Anti-pathogenic compounds, which inhibit quorum sensing (QS) pathways, may be a useful alternative to antibiotics. Staphylococcal QS is encoded by the AGR locus and is responsible for the production of δ-hemolysin. Quantification of δ-hemolysin found in culture supernatants permits the analysis of AGR activity at the translational rather than transcriptional level. We employed reversed phase high performance chromatographic (RP-HPLC) techniques to investigate the anti-QS activity of 168 extracts from 104 Italian plants through quantification of δ-hemolysin. Extracts from three medicinal plants (Ballota nigra, Castanea sativa, and Sambucus ebulus) exhibited a dose-dependent response in the production of δ-hemolysin, indicating anti-QS activity in a pathogenic MRSA isolate.

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Citations

Nov 26, 2013·Future Microbiology·Nadja B Cech, Alexander R Horswill
Sep 23, 2014·Pharmaceutical Biology·Marjan TavakkoliOmidreza Firuzi
Jan 8, 2015·Frontiers in Microbiology·Cassandra L Quave, Alexander R Horswill
Nov 29, 2016·Frontiers in Pharmacology·Kate NelsonCassandra L Quave
Jul 12, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anabela BorgesManuel Simões
Dec 7, 2018·Critical Reviews in Food Science and Nutrition·Jiao LiTian Ding
Jul 16, 2021·Frontiers in Pharmacology·Akram M SalamCassandra L Quave
Oct 29, 2019·Journal of Medicinal Chemistry·Alexander R Horswill, Christopher P Gordon
Sep 7, 2019··Esmael Kelil HajiYılmaz Kaya

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