Quorum sensing signal molecules cause renal tissue inflammation through local cytokine responses in experimental UTI caused by Pseudomonas aeruginosa

Immunobiology
Ravi Kumar GuptaKusum Harjai

Abstract

Quorum sensing (QS) plays a pivotal role in the virulence of Pseudomonas aeruginosa. Urinary tract infections (UTI's) caused by P. aeruginosa leads to tissue destruction and inflammation. Interaction of host immune cells and pathogen at the epithelial surface are regulated by cytokines. Role of virulence factors has been implicated in the induction of renal cytokine responses. However, information regarding the role of QS, an important virulence factor of P. aeruginosa, is lacking. This study examined role of QS signal molecules for their ability to induce pro and anti-inflammatory renal cytokines and inflammation in experimental UTI. For this, both standard parent P. aeruginosa strain (PAO1) capable of producing QS signal molecules and its isogenic single and double mutant strains lacking this ability were used. Mice infected with QS producer strain PAO1, evoked significant renal tissue inflammation and cytokine response with high neutrophil migration and AHL production in vivo. Mild inflammation, low level of renal cytokines and other factors were observed in mice infected with QS single and double mutant strains. These results provide first evidence regarding the role of QS signal molecules and point towards the importance o...Continue Reading

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Citations

Nov 21, 2013·Revista iberoamericana de micología·Janaina De Cássia Orlandi SardiMaria José Soares Mendes-Giannini
Dec 15, 2015·International Journal of Medical Microbiology : IJMM·Cassiano Felippe Gonçalves-de-AlbuquerqueHugo Caire Castro-Faria-Neto
May 15, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C McDermottS Anoopkumar-Dukie
Oct 27, 2018·Nature Communications·Stephanie J ColeVincent T Lee
Apr 28, 2017·Frontiers in Neuroscience·Frederick VerbekeBart De Spiegeleer
Oct 23, 2018·European Journal of Medicinal Chemistry·Barbara ParrinoStella Cascioferro

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