Quotidian changes of genital tract cytokines in human immunodeficiency virus-1-infected women during the menstrual cycle

Open Forum Infectious Diseases
Valerie CortezJulie Overbaugh

Abstract

The role of hormonal changes throughout the menstrual cycle on genital tract inflammation during chronic human immunodeficiency virus (HIV) infection is not well defined, but it has implications for HIV prevention. We assessed daily levels of 26 vaginal cytokines and chemokines from 15 women infected with HIV-1. Taking into account coexisting sexually transmitted infections, behavioral factors, and menstruation, this study illustrates cyclic patterns of granulocyte macrophage colony-stimulating factor, interferon-α2, interleukin (IL)-6, IL-10, macrophage inflammatory protein (MIP)-1α, MIP-1β, and tumor necrosis factor (TNF)-α. Progesterone was associated with levels of granulocyte colony-stimulating factor, IL-1α, and monocyte chemoattractant protein-1. Interferon-α2, IL-6, MIP-1α, MIP-1β, and TNF-α levels predicted HIV shedding, but these associations were heavily influenced by the menstrual cycle.

References

Jan 1, 1973·Journal of Reproduction and Fertility·K S RaoJ F Heremans
Nov 5, 1997·Biochemical and Biophysical Research Communications·R W KellyS C Riley
May 10, 2001·Clinical Obstetrics and Gynecology·L al-Harthi, A Landay
Jun 8, 2004·The Journal of Infectious Diseases·Sarah BenkiJulie Overbaugh
Apr 8, 2011·Science Translational Medicine·Jared M BaetenUNKNOWN Partners in Prevention HSV/HIV Transmission Study Team
Dec 23, 2011·The Journal of Infectious Diseases·Lindi RobertsSalim S Abdool Karim
Jun 8, 2012·American Journal of Reproductive Immunology : AJRI·Colin MacneillJudith Weisz
Aug 11, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Catherine A BlishJulie Overbaugh
Apr 18, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Betsy C HeroldKathryn Anastos

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Citations

Mar 31, 2016·American Journal of Obstetrics and Gynecology·Mariel JaisMimi Ghosh
May 4, 2016·Current HIV/AIDS Reports·Lyle R McKinnon, Quarraisha Abdool Karim
May 6, 2021·Aging Cell·Marta Rodriguez-GarciaCharles R Wira

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