(R)-(+)-β-Citronellol and (S)-(-)-β-Citronellol in Combination with Amphotericin B against Candida Spp

International Journal of Molecular Sciences
Daniele SilvaEdeltrudes Lima

Abstract

The enantiomers (R)-(+)-β-citronellol and (S)-(-)-β-citronellol are present in many medicinal plants, but little is understood about their bioactivity against Candida yeasts. This study aimed to evaluate the behavior of positive and negative enantiomers of β-citronellol on strains of Candida albicans and C. tropicalis involved in candidemia. The minimum inhibitory concentration (MIC) and minimum fungicide concentration (MFC) were determined. The evaluation of growth kinetics, mechanism of action, and association studies with Amphotericin B (AB) using the checkerboard method was also performed. R-(+)-β-citronellol and S-(-)-β-citronellol presented a MIC50% of 64 µg/mL and a MFC50% of 256 µg/mL for C. albicans strains. For C. tropicalis, the isomers exhibited a MIC50% of 256 µg/mL and a MFC50% of 1024 µg/mL. In the mechanism of action assay, both substances displayed an effect on the fungal membrane but not on the fungal cell wall. Synergism and indifference were observed in the association of R-(+)-β-citronellol and AB, while the association between S-(-)-β-citronellol and AB displayed synergism, additivity, and indifference. In conclusion, both isomers of β-citronellol presented a similar profile of antifungal activity. Hence, ...Continue Reading

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Citations

Jul 8, 2020·Pharmaceuticals·Laísa CordeiroEdeltrudes Lima
Sep 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Laísa CordeiroEdeltrudes Lima
Jul 8, 2020·International Journal of Molecular Sciences·Laísa CordeiroEdeltrudes Lima
Oct 8, 2020·Pharmaceuticals·Daianne MedeirosEdeltrudes Lima
Mar 15, 2021·Journal of Environmental Management·María Rosa Pino-OtínDiego Ballestero
Apr 22, 2021·BioMed Research International·Danielle da Nóbrega AlvesRicardo Dias de Castro
Sep 27, 2021·Mycopathologia·Antonio Carlos Vital JúniorVânia Sousa Andrade

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Methods Mentioned

BETA
Assay

Software Mentioned

GraphPad Prism
Statistical Package for The Social Sciences

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