(R)-albuterol decreases immune responses: role of activated T cells

Respiratory Research
Marcela A FerradaPatricia W Finn

Abstract

Racemic albuterol is an equimolar mixture of two isomers, (R) and (S). Whether (R) and (S) isomers and the combination of both exert different effects in immune activation is not well defined. We analyzed the effects of (R+S)-albuterol, (R)-albuterol and (S)-albuterol in a murine model of allergic pulmonary inflammation and in activated T cells. Mice (C57BL/6) sensitized and aerosol challenged with the allergen ovalbumin (OVA) or phosphate buffered saline (PBS) were treated with (R)-albuterol, (S)-albuterol or (R+S)-albuterol. Following administration of (R)-albuterol, allergen induced bronchoalveolar lavage eosinophils and IgE showed a decrease, albeit not significantly by ANOVA. As T cells are important in allergic inflammation, we asked whether (R+S), (R) or (S)-albuterol might differ in effects on T cells and on the activity of the inflammatory transcription factor NF-kappaB. In activated T cells, (R)-albuterol administration decreased levels of inflammatory cytokines and NF-kappaB activity. These studies suggest that (R)-albuterol decreases cytokine secretion and NF-kappaB activity in T cells.

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Citations

Aug 13, 2009·Current Allergy and Asthma Reports·Bill T Ameredes, William J Calhoun
Jun 9, 2009·Pharmacogenetics and Genomics·Harriet CorvolUNKNOWN Study of African-Americans, Asthma, Genes and Environments (SAGE) Investigators
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Feb 16, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ka-Pan LamChih-Hsing Hung

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Methods Mentioned

BETA
bronchoalveolar
ELISA
PMA
PCR
transfection
bronchoalveolar lavage
sandwich immunoassay

Software Mentioned

Primer Express
Sigma Stat

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