(R)-alpha-methylhistamine augments neural, cholinergic bronchospasm in guinea pigs by histamine H1 receptor activation

European Journal of Pharmacology
J A HeyR W Chapman


In the airways, activation of histamine H3-receptors with (R)-alpha-methylhistamine inhibits neurally induced cholinergic contractions in vitro and peptidergic responses in vivo. The role of histamine H3-receptors on the cholinergic bronchoconstriction induced by electrical stimulation of the dorsal medulla in guinea pigs was assessed in this study. There was no evidence for an H3-receptor mediated inhibition of cholinergic bronchospasm in vivo. However, there was potentiation of central cholinergic bronchoconstriction by (R)-alpha-methylhistamine or histamine by a mechanism involving H1-receptors. I.v. (R)-alpha-methylhistamine (0.3-3 mg/kg) or histamine (0.001-0.01 mg/kg) produced a transient bronchospasm and potentiated the bronchoconstriction due to medullary stimulation. These effects of (R)-alpha-methylhistamine and histamine were blocked by the histamine H1-antagonist, chlorpheniramine (30 micrograms/kg i.v.) but not by H2- or H3-receptor antagonists. (R)-alpha-Methyl-histamine did not potentiate the bronchoconstriction due to i.v. methacholine. Other bronchoconstrictor agents such as methacholine and serotonin did not potentiate the CNS-induced bronchospasm.


Jul 1, 1994·European Journal of Pharmacology·R L McLeodJ A Hey
May 12, 1994·European Journal of Pharmacology·M C Koss
Jun 1, 1995·Pharmacology & Therapeutics·R LeursH Timmerman
Jun 12, 2003·European Journal of Pharmacology·Keri E CannonLindsay B Hough
Jan 25, 2005·Nature Reviews. Drug Discovery·R LeursIwan J P de Esch
Jul 4, 2003·British Journal of Pharmacology·Julian CharlesChristine E Wright
Jun 20, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S SuzukiY Majima
Aug 13, 1999·The American Journal of Physiology·M A OlszewskiN E Robinson


Aug 6, 1979·Life Sciences·S S Yen, W Kreutner
Jan 1, 1978·Monographs in Allergy·M A Beaven
Mar 1, 1990·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·R W Chapman, G Danko
May 1, 1987·The Journal of Clinical Investigation·D Weinreich, B J Undem
May 1, 1989·British Journal of Pharmacology·M IchinoseP J Barnes
Dec 1, 1989·Naunyn-Schmiedeberg's Archives of Pharmacology·E SchlickerM Göthert
Apr 25, 1989·European Journal of Pharmacology·M Ichinose, P J Barnes
Jun 10, 1988·European Journal of Pharmacology·L Ea-Kim, N Oudart
May 14, 1987·Nature·J M ArrangJ C Schwartz
May 1, 1988·Naunyn-Schmiedeberg's Archives of Pharmacology·E SchlickerM Göthert
Apr 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·A D Fryer, J Maclagan
Dec 1, 1982·Acta Physiologica Scandinavica·J M Lundberg, A Saria
Dec 1, 1984·British Journal of Pharmacology·A D Fryer, J Maclagan

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