PMID: 3745716Sep 1, 1986Paper

R and S wave changes produced by experimental nontransmural and transmural myocardial infarction

Journal of the American College of Cardiology
D M MirvisJ L Wilson

Abstract

Electrocardiographic R and S wave changes occur after transmural myocardial infarction. It was the purpose of this study to define the spatial characteristics of these changes and their pathologic determinants after nontransmural as well as transmural necrosis. Twenty-six dogs were studied after occlusion of the left circumflex coronary artery for 60 to 240 minutes, followed by reperfusion. Electrocardiographic potentials were recorded before and 1 week after infarction using an 84 electrode array to compute maximal and root-mean-square R and S wave voltages. Infarct size was quantitated by computer-aided evaluation of heart slices stained by triphenyltetrazolium chloride. R and S wave amplitudes after infarction varied widely from one torso site to another in a pattern generally consistent with the inferoposterior location of the infarcted zones. Although changes in peak R and S wave potentials did not significantly correlate with infarct size, differences in pre- and postocclusion root-mean-square R and S wave amplitudes did, with correlation coefficients of -0.79 and -0.63, respectively. Root-mean-square values increased for small lesions and decreased for larger ones. These data indicate that nontransmural as well as transm...Continue Reading

References

Mar 1, 1973·IEEE Transactions on Bio-medical Engineering·D A BrodyR E Ideker
Jul 1, 1983·Journal of Electrocardiology·D M Mirvis
Jan 7, 1982·The New England Journal of Medicine·S T PalmeriG S Wagner
Jun 10, 1982·The New England Journal of Medicine·B Gitler, J A Cooper
Jun 1, 1962·The Bulletin of Mathematical Biophysics·D A BRODY, J C BRADSHAW

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